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TranscriptomicsA compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupy CBF-MYH11/RUNX1 target genes
Different mechanisms for CBF-MYH11 function in acute myeloid Leukemia (AML) with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, interference with transcription factor complex assembly and recruitment of histone deacetylases, all resulting in transcriptional repression of ...
ORGANISM(S): Homo sapiens 
2013-09-09 | E-GEOD-46044 | biostudies-arrayexpress
ProteomicsRab18 BioID Nov 24 2015 McGill University
BioID datasets of wt, Q and S in the absence and presence of oleate. Tetracyclin-induced Rab18-BirA* hybrid proteins stably expressed in HEK293 cells. Included also, NBirA* plus minus oleate induced and expressed as controls.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD016631 | Pride
Rab18 bioid 
TranscriptomicsTranscription profiling by array of Nab2 depletion effect on yeast mRNA
Transcription profiling was performed on the time course of Nab2 protein depletion in THC-Nab2 strain at 0h, 7h, 12h in biological triplicates to access its affect on the composition and structure of mRNA in budding yeast. For the protein depletion experiment THC-NAB2 (THJ collection Y2484, THC-NAB2...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-11 | E-MTAB-981 | biostudies-arrayexpress
TranscriptomicsAlterations in gene expression following knockdown of thioredoxin 1 (TR1) with stable viral transduction
This experiment was to determine if we could observe changes in gene expression following the attenuation of one of the primary redox regulators of cells - thioredoxin reductase 1. The experiment was set up with two cell lines that expressed different basal levels of TR1. LOX cells represent an aggr...
ORGANISM(S): Homo sapiens 
2015-04-28 | E-GEOD-56519 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HNF1beta mutated vs wildtype embryonic kidney cell line HEK293 to identify potential HNF1beta target genes whose activity may be deregulated in human patients
Hepatocyte nuclear factor 1beta (HNF1beta, TCF2) is a tissue-specific transcription factor whose mutation in humans leads to renal cysts, genital malformations, pancreas atrophy and maturity onset diabetes of the young (MODY5). Furthermore, HNF1beta overexpression has been observed in clear cell can...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-GEOD-3308 | biostudies-arrayexpress
GenomicsStaphylococcus aureus strain:CCUG 35601
Staphylococcus aureus strain:CCUG 35601 Genome sequencing and assembly
PRJNA489191 | ENA
TranscriptomicsRNAi of XAC1 (Tb927.7.2780) in Trypanosoma brucei bloodstream forms
Gradient fractions of RNAi of XAC1 (Tb927.7.2780) in Trypanosoma brucei bloodstream forms. RNAi was induced using tetracycline and cell extracts were fractionated into polysomal and monosome-non-ribosome-associated fractions.
ORGANISM(S): Trypanosoma brucei 
2017-12-16 | E-MTAB-6239 | biostudies-arrayexpress
TranscriptomicsZC3H5 RNAi RNAseq
ZC3H5-TAP expressing cells were transfected with RNAi targeting ZC3H5. Two clones where used and samples collected 9 and 12 hours after RNAi induction (Tetracycline 250ng/ml).
ORGANISM(S): Trypanosoma brucei 
2020-05-28 | E-MTAB-9088 | biostudies-arrayexpress
TranscriptomicsCEA_SGF:E00004#TetOFF_Stat3F
The goal of this study was to identify the target genes of Stat3 involved in murine ES cell self-renewal. To achieve this goal, we used the Gs2 ES cell line expressing an inducible dominant negative mutant of Stat3 (Stat3F) in wich Y705 is mutated to phenilalanine. The Gs2 ES cells are routinely mai...
ORGANISM(S): Mus musculus 
2004-07-01 | GSE1151 | GEO
TranscriptomicsRNA-seq, term-seq and tagRNA-seq of M. tuberculosis strains H37Rv and RhoDUC strains induced for Rho depletion at times 0H, 1.5H, 3H, 4.5H and 6H
Accurately controlled termination of transcription is critical for gene expression and adaptation to changing environments in bacteria. The aim of this study was to define transcription termination sites in Mycobacterium tuberculosis at nucleotide resolution. To this end, we used a combination of t...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2022-11-01 | E-MTAB-11753 | biostudies-arrayexpress
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