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ProteomicsA Circular RNA Controls Ribosomal RNA Maturation and Atherosclerosis in Humans
Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their role in human health and disease remains obscure. Here, we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome ...
ORGANISM(S): Homo sapiens (Human) 
2016-06-10 | PXD001769 | Pride
Circanril rna Pulse-silac Rna pulldowns Lc-ms/ms 
TranscriptomicsTranscription profiling of mouse model of Wilson disease reveals specific changes of liver transcriptome in the early stages of copper accumulation
Wilson disease (WD) is a severe metabolic disorder caused by genetic inactivation of copper-transporting ATPase ATP7B. In WD, copper accumulates in several tissues, particularly in the liver, inducing marked time-dependent pathological changes. To identify initial events in the copper-dependent de...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5348 | biostudies-arrayexpress
TranscriptomicsDissecting the Genetics of the Human Transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci
Genetics of gene expression (eQTLs or expression QTLs) has proved an indispensable tool for understanding biological pathways and pathomechanisms of trait associated SNPs. However, power of most genome-wide eQTL studies is still limited. We performed a large eQTL study in peripheral blood mononuclea...
ORGANISM(S): Homo sapiens 
2015-06-29 | E-GEOD-65907 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Nrf2 knockout caused by ROS-mediated insulin/IGF-1 resistance
The liver is frequently challenged by surgery-induced metabolic overload, viruses, or toxins, which induce the formation of reactive oxygen species. To determine the effect of oxidative stress on liver regeneration and to identify the underlying signalling pathways, we studied liver repair in mice l...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8969 | biostudies-arrayexpress
ProteomicsA Circular RNA Controls Ribosomal RNA Maturation and Atherosclerosis in Humans
Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their role in human health and disease remains obscure. Here, we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080698 | MassIVE
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