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Transcription factor cooperation and competition
Early dorsal telencephalon development is coordinated by an interplay of transcription factors that exhibit a graded expression pattern in neural progenitors. How they function together to orchestrate cortical development remains largely unknown. The Emx2 and Dmrta2 genes encode TFs that are express...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-04 | PXD056238 | Pride
Early dorsal telencephalon development is coordinated by an interplay of transcription factors that exhibit a graded expression pattern in neural progenitors. How they function together to orchestrate cortical development remains largely unknown. The Emx2 and Dmrta2 genes encode TFs that are express...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-04 | PXD061688 | Pride
Transcription factors have to distinguish proper targets from a large pool of potential binding sites. Here we explore how MSL2 and CLAMP cooperate to bind their specific targets. Using an in vitro chromatin reconstitution system and by mutating the interaction domain of CLAMP we show how direct and...
ORGANISM(S): Drosophila melanogaster 
2023-07-27 | GSE224981 | GEO
Peptidyl-prolyl cis/trans isomerases (PPIases) are enzymes that assist in protein folding around proline-peptide bonds, and often possess chaperone activity. Staphylococcus aureus encodes three PPIases; PrsA, PpiB and Trigger factor (TF). Previous work by our group demonstrated a role for both PrsA ...
ORGANISM(S): Staphylococcus aureus 
2021-01-28 | PXD023811 | Pride
Massively Parallel Binding Assay (MPBA) reveals limited transcription factor cooperation, challenging models of specificity
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