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Proteomicsolfactory proteomics in aged Tg2576 mice
Olfaction is often deregulated in Alzheimer´s disease (AD) patients, being also impaired in transgenic Tg2576 AD mouse model, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little is known about the molecular mechanisms that accompany the neurodegenerat...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-02 | PXD007795 | Pride
Alzheimer Olfactory bulb Proteomics Neurodegeneration 
ProteomicsTime-dependent olfactory proteomics in Tg2576 mice
Olfaction is often deregulated in Alzheimer´s disease (AD) patients, being also impaired in transgenic Tg2576 AD mouse model, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little is known about the molecular mechanisms that accompany the neurodegenerat...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-28 | PXD007813 | Pride
Olfactory bulb Proteomics Alzheimer 
TranscriptomicsExpression profiling of laser-microdissected tissue from Tg2576 plaque-depositing mouse model of Alzheimer's disease
Amyloid-M-CM-^_ (AM-CM-^_) plaques are pathological hallmarks of Alzheimer disease. However, the precise neuropathological changes that occur in brain in response to amyloid deposition are largely unknown. To study the molecular mechanism(s) responsible for AM-CM-^_-mediated neuropathology, we perfo...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-15056 | biostudies-arrayexpress
TranscriptomicsHippocampal gene expression profiling of a model of Alzheimer`s Disease upon treatment with the ACE inhibitor captopril
Extracellular senile plaques of amyloid beta (Abeta) are a pathological hallmark in brain of patients with Alzheimer`s Disease (AD). Abeta is generated by the amyloidogenic processing of the amyloid precursor protein (APP). Concomitant to Abeta load, AD brain is characterized by an increase in prote...
ORGANISM(S): Mus musculus 
2013-05-14 | E-GEOD-46871 | biostudies-arrayexpress
TranscriptomicsTg2576 and wild-type mice treated with PDE9A-inhibitor
Many forms of synaptic plasticity are critically dependent upon production of cGMP to trigger activity-dependent increases in synaptic size and strength. Phosphodiesterase 9A (PDE9A) is a high affinity, cGMP-specific phosphodiesterase with widespread distribution in the central nervous system. Inhib...
ORGANISM(S): Mus musculus 
2012-03-09 | E-GEOD-36237 | biostudies-arrayexpress
ProteomicsInvestigation of TOMM6 in brains from Tg2576 mice
The protein TOMM6 (translocase of outer mitochondrial membrane 6) was identified as an interacting protein of phospho-S670-GRK2 (G protein-coupled receptor kinase 2 phosphorylated at serine 670) in brain specimens (frontal cortex and hippocampus) of 12-month-old Tg2576 Alzheimer (AD) model mice. Mit...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-16 | PXD073643 | Pride
Tg2576 mouse brain Mitochondria 
UnknownDefined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain.
Not available
S-EPMC6588085 | biostudies-literature
TranscriptomicsLaser-microdissected tissue from Tg2576 and APPPS1 plaque-depositing mouse model of Alzheimer's disease
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-15128 | biostudies-arrayexpress
UnknownOutstanding Phenotypic Differences in the Profile of Amyloid-β between Tg2576 and APPswe/PS1dE9 Transgenic Mouse Models of Alzheimer's Disease.
Not available
S-EPMC4981901 | biostudies-literature
UnknownLocal perfusion of capillaries reveals disrupted beta-amyloid homeostasis at the blood-brain barrier in Tg2576 murine Alzheimer's model.
Not available
S-EPMC10666337 | biostudies-literature
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