Proteomics

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Time-dependent olfactory proteomics in Tg2576 mice


ABSTRACT: Olfaction is often deregulated in Alzheimer´s disease (AD) patients, being also impaired in transgenic Tg2576 AD mouse model, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little is known about the molecular mechanisms that accompany the neurodegeneration of olfactory structures in Tg2576 mice. For that, we have applied proteome-wide approaches to probe molecular disturbances in the olfactory bulb (OB) dissected from Tg2576 mice respect to age matched wild-type littermates (2 and 6 months of age).

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mus musculus  

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Enrique Santamaría  

LAB HEAD: Enrique Santamaria

PROVIDER: PXD007813 | Pride | 2019-06-28

REPOSITORIES: pride

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Publications

Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer's Disease.

Lachen-Montes Mercedes M   González-Morales Andrea A   Palomino Maialen M   Ausin Karina K   Gómez-Ochoa Marta M   Zelaya María Victoria MV   Ferrer Isidro I   Pérez-Mediavilla Alberto A   Fernández-Irigoyen Joaquín J   Santamaría Enrique E  

Frontiers in aging neuroscience 20190611


The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer's disease (AD), little is known about the initial molecular disturbances that accompany the AD development at olfactory level. We have interrogated the time-dependent OB molecular landscape in Tg2576 AD mice prior to the appearance of neuropathological amyloid plaques (2-, and 6-month-old), using combinatorial omics analysis. The metabolic mo  ...[more]

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