Proteomics

Dataset Information

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Proteomic analysis of B16-MDSCs


ABSTRACT: In order to analyse the B16-MDSCs proteome in a large-scale format, we used a multi-dimensional fractionation approach which combines peptide chromatographic fractionation strategies coupled to mass spectrometry.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mus musculus  

TISSUE(S): Cell Culture

DISEASE(S): Melanoma

SUBMITTER: Enrique Santamaría  

LAB HEAD: Enrique Santamaria

PROVIDER: PXD001103 | Pride | 2016-07-07

REPOSITORIES: pride

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Publications

A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice.

Liechtenstein Therese T   Perez-Janices Noemi N   Gato Maria M   Caliendo Fabio F   Kochan Grazyna G   Blanco-Luquin Idoia I   Van der Jeught Kevin K   Arce Frederick F   Guerrero-Setas David D   Fernandez-Irigoyen Joaquin J   Santamaria Enrique E   Breckpot Karine K   Escors David D  

Oncotarget 20140901 17


Myeloid-derived suppressor cells (MDSCs) exhibit potent immunosuppressive activities in cancer. MDSCs infiltrate tumors and strongly inhibit cancer-specific cytotoxic T cells. Their mechanism of differentiation and identification of MDSC-specific therapeutic targets are major areas of interest. We have devised a highly efficient and rapid method to produce very large numbers of melanoma-infiltrating MDSCs ex vivo without inducing tumors in mice. These MDSCs were used to study their differentiati  ...[more]

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