Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Melanocyte, Cell Culture
DISEASE(S): Melanoma
SUBMITTER: Pilar Ximenez-Embun
LAB HEAD: Javier Muñoz Peralta
PROVIDER: PXD006650 | Pride | 2022-02-28
REPOSITORIES: Pride
Karras Panagiotis P Riveiro-Falkenbach Erica E Cañón Estela E Tejedo Cristina C Calvo Tonantzin G TG Martínez-Herranz Raúl R Alonso-Curbelo Direna D Cifdaloz Metehan M Perez-Guijarro Eva E Gómez-López Gonzalo G Ximenez-Embun Pilar P Muñoz Javier J Megias Diego D Olmeda David D Moscat Jorge J Ortiz-Romero Pablo L PL Rodríguez-Peralto Jose L JL Soengas María S MS
Cancer cell 20181220 1
Modulators of mRNA stability are not well understood in melanoma, an aggressive tumor with complex changes in the transcriptome. Here we report the ability of p62/SQSTM1 to extend mRNA half-life of a spectrum of pro-metastatic factors. These include FERMT2 and other transcripts with no previous links to melanoma. Transcriptomic, proteomic, and interactomic analyses, combined with validation in clinical biopsies and mouse models, identified a selected set of RNA-binding proteins (RBPs) recruited ...[more]