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Unknown"Dual Disease" TgAD/GSS mice exhibit enhanced Alzheimer's disease pathology and reveal PrPC-dependent secretion of Aβ.
Not available
S-EPMC6562043 | biostudies-literature
ProteomicsMulti-omics approach to characterize sex-specific metabolic alterations in triple-transgenic Alzheimer's mouse brain
We aimed to characterise alterations in metabolic pathways and proteome composition in a mouse model of Alzheimer disease (AD). We specifically aimed to evaluate how these differences may be sex-specific by integrative multi-omics analysis (metabolites, lipids, proteins).
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD033164 | Pride
Proteomics Brain Metabolomics Tgad mouse Data-independent acquisition Alzheimer's disease 
GenomicsmiR-449a may prevent neurodegeneration in Alzheimer's Disease by repressing the cell cycle machinery in neurons
Aberrant activation of cell cycle of terminally-differentiated neurons results in their apoptosis and is known to contribute to neuronal loss in various neurodegenerative disorders like Alzheimer's Disease. However, the mechanisms that regulate Cell Cycle Related Neuronal Apoptosis (CRNA) are poorly...
ORGANISM(S): Mus musculus 
2024-08-19 | GSE201209 | GEO
UnknownmiR-449a mediated repression of the cell cycle machinery prevents neuronal apoptosis.
Not available
S-EPMC11419829 | biostudies-literature
UnknownNovel murine closed-loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration.
Not available
S-EPMC11911048 | biostudies-literature
GenomicsmiR-449a may prevent neurodegeneration in Alzheimer's Disease by repressing the cell cycle machinery in neurons
miR-449a may prevent neurodegeneration in Alzheimer's Disease by repressing the cell cycle machinery in neurons
PRJNA830358 | ENA
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