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TranscriptomicsTGFB signaling effect on cultured NHLF cells
TGFβ activates a signal transduction cascade that results in the microRNAs and genes transcription. The objective of this study is to identify miRNAs which are regulated through TGFB signaling pathway Cultured NHLF cells at 30-50% confluence were treated with 5 ng/mL TGFB1 or DMSO.
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-27156 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling of Hic-5 and TGFB in WPMY fibroblasts
Identifying the effect of the co-regulator Hic-5 (TGFB1I1) and TGFB on the transcriptional profile of WPMY human prostate fibroblast cells with view to further elucidating the broader biological role of Hic-5 and TGFB on fibroblast. Knockdown of Hic5 for 48 hours in PShTert-AR cells significantly al...
ORGANISM(S): Homo sapiens 
2013-08-26 | E-GEOD-47354 | biostudies-arrayexpress
GenomicsDMD-TGFb-SETDB1
DMD-TGFb-SETDB1
PRJEB63300 | ENA
TranscriptomicsGene expression profiling of NSCLC cell lines upon TGFb-induced epithelial-mesenchymal transition (EMT)
Epithelial-mesenchymal transition has been implicated in tumor metastasis, cancer drug resistance and cancer stem cell features. In this study, we examined gene expression profiles of three non-small cell lung cancer cell lines, before and after experimentally induced EMT. We modeled epitheial-mese...
ORGANISM(S): Homo sapiens 
2014-11-19 | E-GEOD-49644 | biostudies-arrayexpress
ModelsStrasen2018 - TGFb SMAD Signalling - Dose dependent dynamics upon TGFb stimulation
This model simulates TGFb dose dependent kinetics of The SMADs. TGFb ligand dose applied are 1pM, 2.5pM, 5pM, 25pM, and 100pM as explained in the manuscript.
2024-09-02 | BIOMD0000000989 | BioModels
TranscriptomicsTGFb dependent Treg conversion and the inhibition of conversion by IL6
Analysis of CD4+ cells activated with anti-CD3 and cultured in the presence of IL2. The effects of TGFb and IL6 on Treg conversion were analyzed to discover methods of inhibiting Treg conversion and/or Treg functional inhibition. CD4+ T-cells were enriched from lymph nodes of Foxp3-GFP mice and cult...
ORGANISM(S): Mus musculus 
2010-04-07 | E-GEOD-21027 | biostudies-arrayexpress
TranscriptomicsGene expression in tolerogenic TGFb-treated macrophages
F4/80+ macrophages treated with TGFb2 are potently tolerogenic. Our understanding of the molecular mechanisms mediating the development of these tolerogenic properties is incomplete. We used microarray analysis to identify molecules that are involved in the tolerogenic mechanisms in murine TGFb-tre...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-45382 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human stomach cancer, gastritis and normal stomach tissue shows that MicroRNAs regulated by E2F1 affect TGFb-dependent cell cycle arrest and apoptosis
A microarray expression profiling of stomach cancer, gastritis and normal samples reveals that microRNAs regulated by E2F1 affect TGFb-dependent cell cycle arrest and apoptosis.
ORGANISM(S): Homo sapiens 
2008-03-01 | E-TABM-434 | biostudies-arrayexpress
GenomicsTGFb-induced transcriptome profile in cancer cell lines
TGFb-induced transcriptome profile in cancer cell lines
PRJNA1145878 | ENA
UnknownA chronic signaling TGFb zebrafish reporter identifies immune response in melanoma.
Not available
S-EPMC11178360 | biostudies-literature
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