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ProteomicsProteomic profiling of TGFBIp-null mouse corneas reveals minor changes in the extracellular matrix composition supportive of TGFBI knockdown as therapy against TGFBI-linked corneal dystrophies
TGFBIp is a constituent of the extracellular matrix in many human tissues including the cornea, where it is one of the most abundant proteins expressed. TGFBIp interacts with type I, II, IV, VI and XII collagens as well as several members of the integrin family, suggesting that it plays an important...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-14 | PXD006494 | Pride
Ecm Tgfbip Cornea Periostin Itraq Lc-ms/ms 
TranscriptomicsGene expression profiles of NIH3T3 cells stably transfected with the plasmids encoding the wild type PreS/S gene or the nonsense mutant gene (sW182*) of HBV.
Background and Aims: Whether hepatitis B virus (HBV) could play a direct role in hepatocarcinogenesis remains uncertain. The 3' end nonsense mutations of HBV PreS/S gene have been found to encode transcriptional transactivation activity, suggesting these mutations may contribute to HBV-associated on...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-50180 | biostudies-arrayexpress
ProteomicsProtein composition of TGFBI-R124C and TGFBI-R555W associated aggregates suggests multiple mechanisms leading to Lattice and Granular corneal dystrophy
Transforming Growth Factor Beta-induced (TGFBI)-related dystrophies constitute the most common heritable forms of corneal dystrophy worldwide. However, other than the underlying genotypes of these conditions, a limited knowledge exists of the exact pathomechanisms of these disorders. This study expa...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079985 | MassIVE
ProteomicsProteome of DiFi and CC-CR supermeres purified by FPLC with or without additional affinity purification for TGFBi
The cell seretome is diverse and contains extracellular secreted vesicles (EVs) as well as non-vesicular extracellular nanoparticles (NVEPs) called exomeres and supermeres, all of which carry different kinds of cell signaling cargos. One supermere enriched cargo is transforming growth factor beta in...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD066888 | Pride
Supermeres Fplc Affinity purification Proteomics 
ProteomicsProtein composition of TGFBI-R124C and TGFBI-R555W associated aggregates suggests multiple mechanisms leading to Lattice and Granular corneal dystrophy
Transforming Growth Factor Beta-induced (TGFBI)-related dystrophies constitute the most common heritable forms of corneal dystrophy worldwide. However, other than the underlying genotypes of these conditions, a limited knowledge exists of the exact pathomechanisms of these disorders. This study expa...
ORGANISM(S): Homo sapiens (Human) 
2015-11-18 | PXD002236 | Pride
Granular corneal dystrophy Lattice corneal dystrophy Human cornea 
GenomicsEpigenetic Silencing of TGFBI Confers Resistance to Trastuzumab in Human Breast Cancer
Epigenetic Silencing of TGFBI Confers Resistance to Trastuzumab in Human Breast Cancer
PRJNA509689 | ENA
GenomicsPUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension
PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension
PRJNA1477067 | ENA
GenomicsPUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension
PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension
PRJNA1476494 | ENA
UnknownProteomic profiling of TGFBI-null mouse corneas reveals only minor changes in matrix composition supportive of TGFBI knockdown as therapy against TGFBI-linked corneal dystrophies.
Not available
S-EPMC5760277 | biostudies-literature
GenomicsPUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension II
PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension II
PRJNA1477619 | ENA
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