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ProteomicsInterleukin-6 induced ‘acute’ response promotes Th1 anti-tumor immunity in cryo-thermal therapy: shotgun proteomics
Cryo-thermal therapy has been proven to be a promising novel systemic strategy for advanced breast cancer, resulting in higher incidence of tumor regression and enhanced remission of metastasis. The mechanism by which such strategy boosts the anti-tumor activity remains unclear. To gain a system-wid...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-12 | PXD003136 | Pride
Acute phase response Th1 anti-tumor immunity Cryo-thermal therapy Interleukin-6 Parallel reaction monitoring 
GenomicsBlockade of PF4-induced Th1-Treg polarization enhances anti-tumor immunity
Blockade of PF4-induced Th1-Treg polarization enhances anti-tumor immunity
PRJNA1055150 | ENA
ModelsEftimie2010 - immunity to melanoma
The paper describes a model of immunity to melanoma. Created by COPASI 4.25 (Build 207) This model is described in the article: Modeling anti-tumor Th1 and Th2 immunity in the rejection of melanoma Raluca Eftimie, Jonathan L. Bramson, David J.D. Earn Journal of Theoretical Biology 265 (2010) 4...
2024-09-02 | BIOMD0000000768 | BioModels
Immuno-oncology 
GenomicsIL-16 promotes anti-tumor immunity via establishing a Th1-dominant tumor microenvironment [RNA-seq]
IL-16 promotes anti-tumor immunity via establishing a Th1-dominant tumor microenvironment [RNA-seq]
PRJNA1039765 | ENA
GenomicsBlockade of PF4-induced Th1-Treg polarization enhances anti-tumor immunity (Bulk RNA-Seq)
Blockade of PF4-induced Th1-Treg polarization enhances anti-tumor immunity (Bulk RNA-Seq)
PRJNA1057209 | ENA
GenomicsTh1-poised naïve CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease
Th1-poised naïve CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease
PRJNA1200828 | ENA
TranscriptomicsBlockade of PF4-induced Th1-Treg polarization enhances anti-tumor immunity
The tumor microenvironment (TME) contains various immune-suppressive cells such as regulatory T cells (Tregs) and M2-like tumor associated macrophages (TAMs) that express the enzyme arginase I (Arg1). T helper 1-polarized Treg (Th1-Treg) is a Treg subset that markedly accumulate in tumor tissues, su...
ORGANISM(S): Mus musculus 
2024-11-07 | GSE251735 | GEO
TranscriptomicsBlockade of PF4-induced Th1-Treg polarization enhances anti-tumor immunity (Bulk RNA-Seq)
The tumor microenvironment (TME) contains various immune-suppressive cells such as T helper 1-polarized regulatory T cells (Th1-Tregs). However, little is known about the mechanism behind the abundant presence of Th1-Tregs in TME. In this work, we demonstrate that selective depletion of arginase I (...
ORGANISM(S): Mus musculus 
2024-11-07 | GSE252052 | GEO
TranscriptomicsIL-16 promotes anti-tumor immunity via establishing a Th1-dominant tumor microenvironment [RNA-seq]
Overcoming immunosuppression in tumor microenvironment (TME) is fundamental to the development of novel cancer immunotherapies. Herein, we revealed an unrecognized role of IL-16 in shaping anti-tumor immunity. Compared with healthy subjects, cancer patients had impaired production of IL-16, which wa...
ORGANISM(S): Mus musculus 
2025-01-20 | GSE247579 | GEO
GenomicsTOX drives TH1 CD4+ T cell effector function, anti-tumor immunity, and pathogenicity in autoimmune diseases
TOX drives TH1 CD4+ T cell effector function, anti-tumor immunity, and pathogenicity in autoimmune diseases
PRJNA1415780 | ENA
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