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TranscriptomicsExpression Data from murine control and IL6ralpha-deficient macrophages stimulated with Interleukin-6
IL-6 induces IL4ralpha expression in macrophages. This mechanism is necessary to promote macrophage polarization towards an M2-phenotype and is crucial to limit the inflammatory response both upon obesity and LPS-endotoxemia. In this dataset, we include the expression data obtained from primary muri...
ORGANISM(S): Mus musculus 
2014-03-30 | E-GEOD-47426 | biostudies-arrayexpress
TranscriptomicsTranscriptome profile of in vitro produced blastocysts derived from in vitro matured oocytes exposed to exogenous interleukin-6
This study explores the biological role of interleukin-6 (IL-6) as a supplement during in vitro maturation (IVM) of porcine oocytes, aiming to enhance embryonic development and reduce apoptosis following in vitro fertilization (IVF). The objective was to determine whether IL-6 supplementation alters...
ORGANISM(S): Sus scrofa 
2025-06-30 | E-MTAB-15241 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cholangiocarcinoma cells (cholangiocytes) expressing IL-6
The association between chronic inflammation and the development and progression of malignancy is exemplified in the biliary tract where persistent inflammation strongly predisposes to cholangiocarcinoma. The inflammatory cytokine interleukin-6 (IL-6) enhances tumor growth in cholangiocarcinoma by a...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-11883 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of rat ventricular myocytes cultured with recombinant human interleukin 6
Ventricular myocytes were isolated from adult male Sprague-Dawley rats (250-350g) by collagenase digestion. Cells were cultured with recombinant human interleukin 6 for six hours prior to isolation total RNA by RNeasy mini kit (Qiagen). RNA was amplified and labelled using the Illumina TotalPrep R...
ORGANISM(S): Rattus norvegicus 
2011-07-11 | E-MTAB-344 | biostudies-arrayexpress
TranscriptomicsDNA microarray analysis of the anti-inflammatory effects of PDTC on IL-6 signaling in HepG2 cells
Interleukin-6 (IL-6) is a proinflammatory cytokine that exerts a wide range of cellular, physiological and pathophysiological responses. Pyrrolidine dithiocarbamate (PDTC) antagonizes the cellular responsiveness to IL-6 through impairment in STAT3 activation and downstream signaling. Here, a transcr...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-14632 | biostudies-arrayexpress
ProteomicsLactobacillus Probiotic Cell-free Supernatants and Vitamin D Influence Interleukin-6 Production and Mitigate Oral Periodontopathogens-induced Cytotoxicity
Oral eubiosis is of utmost importance for local and systemic health. Consolidated habits, as excessive alcohol consumption, smoke, inappropriate oral hygiene, and western diet, exert detrimental effects on oral microbiota composition and function. This leads to caries, gingivitis, and periodontitis,...
ORGANISM(S): Lacticaseibacillus casei Limosilactobacillus reuteri Lacticaseibacillus rhamnosus 
2025-05-26 | PXD059098 | Pride
Mass-spectrometry Interleukin-6 Vitamin d Lactobacillus probiotic Proteomics 
GenomicsRNA sequencing of blood-brain barrier cells exposed to interleukin-6
RNA sequencing of blood-brain barrier cells exposed to interleukin-6
PRJNA575504 | ENA
ProteomicsInterleukin-6 induced ‘acute’ response promotes Th1 anti-tumor immunity in cryo-thermal therapy: shotgun proteomics
Cryo-thermal therapy has been proven to be a promising novel systemic strategy for advanced breast cancer, resulting in higher incidence of tumor regression and enhanced remission of metastasis. The mechanism by which such strategy boosts the anti-tumor activity remains unclear. To gain a system-wid...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-12 | PXD003136 | Pride
Acute phase response Th1 anti-tumor immunity Cryo-thermal therapy Interleukin-6 Parallel reaction monitoring 
TranscriptomicsRole of Interleukin-6 in Influenza Pandemic A (H1N1pdm) Infection in Mice
Profile of host response in C57BL6/J mice infected with A/Mexico/4108/2009 (H1N1), spanning days 1 through 6 post-infection. Focused analysis on the involvement of IL-6 in the host response. Total RNA obtained from lung tissue collected from infected C57BL6/J mice at t = 1, 2, 3, 4, 5, 6 days post-...
ORGANISM(S): Mus musculus 
2012-06-24 | E-GEOD-31022 | biostudies-arrayexpress
GenomicsVirally encoded interleukin-6 (vIL-6) coordinates with human IL-6 to modulate cytokine expression during KSHV infection
Virally encoded interleukin-6 (vIL-6) coordinates with human IL-6 to modulate cytokine expression during KSHV infection
PRJNA1335958 | ENA
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