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TranscriptomicsChemical Inhibition of the RORγt-dependent Transcriptional Network in Th17 cells [RNA-Seq 2]
RORγt is a transcription factor required for T helper 17 (Th17) cell development. We identified three RORγt-specific inhibitors that suppress Th17 cell responses including Th17 cell-mediated autoimmune disease. We systemically characterized RORγt binding data in the presence and absence of drug with...
ORGANISM(S): Mus musculus 
2014-04-17 | E-GEOD-56240 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human Th17 cell differentiation
The study aims at identifying transcriptional changes induced by in vitro polarization of human cord blood CD4+ cells towards Th17 subtype with combination of IL6, IL1b and TGFb by using timeseries data. In this study, we identified gene expression changes characterizing early stages of human Th17 c...
ORGANISM(S): Homo sapiens 
2012-05-03 | E-GEOD-35103 | biostudies-arrayexpress
TranscriptomicsGene array for identifying molecules involved in IL-10 regulation during Th17 polarization
IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. Gene array analysis on Stat6 and T-bet double deficient Th17 cells identified the Th2 transcription factor c-Maf to be synergistically up-regulated by IL-6 plus TGFbeta, and associated with Th17 IL-10 pr...
ORGANISM(S): Mus musculus 
2009-03-03 | E-GEOD-15029 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis of Th22 and Th17 cells
Microarray was used to delineate the global gene expression profile underlying the specific developmental program of two divergent antigen-specific T helper subsets (Th22 versus Th17) by identifying upregulation or downregulation of key lineage-determining transcription factors, cytokines, chemokine...
ORGANISM(S): Mus musculus 
2013-01-29 | E-GEOD-42332 | biostudies-arrayexpress
TranscriptomicsPopulation transcriptional profiling of KO or WT cells,, differentiated in vitro for 48-96h towards Th17 cells
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75104 | biostudies-arrayexpress
TranscriptomicsPopulation transcriptional profiling of in vitro polarized Th17 cells, either sorted for IL17A/GFP+ or unsorted
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75103 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional profiling of Th17 cells, differentiated in vitro for 48h [TGFB1_IL6-48h]
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75110 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Wild Type, DDX5 knockout, RORc knockout, RmrpG262T knockin T helper 17 cell Transcriptomes [RNA-seq]
Purpose: The goals of this study are to compare in vitro polarized T helper 17 cell transcriptome profiling (RNA-seq) in different genetic background. Methods: Th17 mRNA profiles of 96hrs in vitro cultured T helper 17 cells from wild-type and mutant mice were generated by deep sequencing, using Ill...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-70108 | biostudies-arrayexpress
TranscriptomicsRNA-seq of in vitro-generated murine T helper 17 cells
T helper (Th) 17 cells form a T cell subset which is crucial to maintain immunity against extracellular bacteria and fungi at epithelial barriers, but Th17 cells are also enriched at sites of inflammation in autoimmune disease. These sites are commonly characterised by adverse environmental conditio...
ORGANISM(S): Mus musculus 
2017-06-14 | E-MTAB-5692 | biostudies-arrayexpress
GenomicsGenome-wide regulatory analysis reveals T-bet controls Th17 lineage differentiation through direct suppression of IRF4
The complex relationship between Th1 and Th17 cells is incompletely understood. The transcription factor T-bet is best known as the master regulator of Th1 lineage commitment. However, attention is now focused on the repression of alternate T cell subsets mediated by T-bet, particularly the Th17 lin...
ORGANISM(S): Mus musculus 
2013-12-03 | E-GEOD-40623 | biostudies-arrayexpress
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