Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Nir Yosef
PROVIDER: E-GEOD-56240 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Xiao Sheng S Yosef Nir N Yang Jianfei J Wang Yonghui Y Zhou Ling L Zhu Chen C Wu Chuan C Baloglu Erkan E Schmidt Darby D Ramesh Radha R Lobera Mercedes M Sundrud Mark S MS Tsai Pei-Yun PY Xiang Zhijun Z Wang Jinsong J Xu Yan Y Lin Xichen X Kretschmer Karsten K Rahl Peter B PB Young Richard A RA Zhong Zhong Z Hafler David A DA Regev Aviv A Ghosh Shomir S Marson Alexander A Kuchroo Vijay K VK
Immunity 20140401 4
We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including Th17-cell-mediated autoimmune disease. We systemically characterized RORγt binding in the presence and absence of drugs with corresponding whole-genome transcriptome sequencing. RORγt acts as a direct activator of Th17 cell signature genes and a direct repressor of signature genes from other T cell lineages; its strongest transcriptional effects are ...[more]