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TranscriptomicsDefining a Th9 transcriptome
Microarray analyses were performed to compare gene expression in cultured mouse Th9, Th2 and Treg cells and resting versus activated Th9 cells. Three replicates were analyzed for each culture condition; Th9 unstim, Th2 unstim, Treg unstim, Th9 stim
ORGANISM(S): Mus musculus 
2014-03-26 | E-GEOD-44937 | biostudies-arrayexpress
GenomicsOpposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression
Interleukin 9 (IL-9) is a γc-family cytokine that is highly produced by T-helper 9 (Th9) cells and regulates a range of immune responses, including allergic inflammation. Here we show that IL-2–JAK3–STAT5 signaling is required for Th9 differentiation, with critical STAT5 binding sites in the Il9 (th...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-41317 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Th9 CD4+ T cells differentiated with or without Il-1beta
We report that the Th9 differenciation program is boosted in presence of Il-1beta Examination of the expression profile of Th9 CD4+ T cells after 1 hour and 3 days of differentiation and after in vivo injection
ORGANISM(S): Mus musculus 
2014-05-23 | E-GEOD-54697 | biostudies-arrayexpress
ProteomicsProteome analysis revealed the essential functions of protein phosphatase PP2A in the induction of Th9 cells
we performed proteome analysis of Th9 cells to understand the involvement of proteins that might be crucial for the anti-tumor functions of Th9 cells. Here we show for the first time a comprehensive proteomic analysis of murine Th0 and Th9 cells, which identified 1451 total proteins among which 1367...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD019506 | Pride
Proteomics Pp2a Mass spectrometry Th9 cells 
TranscriptomicsTranscriptional profiling of human Th9 T cell clones treated with GW9662 against untreated control
To investigate the role of PPAR-γ in human TH cells, transcriptional response of activated “TH9” clones to treatment with GW9662, a potent PPAR-γ antagonist was assessed. “TH9” cell clones were incubated with GW9662 for 48h and activated with αCD3/2/28 for 12 h. Transcriptomic profiling was performe...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12197 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human in vitro primed Th1, Th2, Th9 and Treg T cells
To test whether human in vitro primed Th9 cells recapitulate the core pathogenic Th2 cell phenotype, we differentiated naïve T cells into Th1 (IL-12), Th2 (IL-4), Th9 (IL-4+TGF-β), and iTreg (TGF-β). After 7 days transcriptomic profiling by bulk RNA-seq was performed.
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12199 | biostudies-arrayexpress
GenomicsThe transcription factor BATF3 regulates the differentiation of TH9 cells and TH9-driven mucosal pathologies
The transcription factor BATF3 regulates the differentiation of TH9 cells and TH9-driven mucosal pathologies
PRJNA418449 | ENA
TranscriptomicsTranscriptional profiling of human in vitro primed Th9 T cells (day 20) treated with GW9662 against untreated control
To investigate the role of PPAR-γ in human TH cells, transcriptional response in vitro primed Th9 cells to treatment with GW9662, a potent PPAR-γ antagonist was assessed. In vitro primed Th9 cells (day 20) were incubated with GW9662 for 48h. Transcriptomic profiling was performed by bulk RNA-seq. To...
ORGANISM(S): Homo sapiens 
2024-11-29 | E-MTAB-14444 | biostudies-arrayexpress
GenomicsLoss of YTHDF2 enhances Th9 programming and CAR-Th9 cell antitumor efficacy
Loss of YTHDF2 enhances Th9 programming and CAR-Th9 cell antitumor efficacy
PRJNA1175660 | ENA
UnknownDeleterious Role of Th9 Cells in Pulmonary Fibrosis.
Not available
S-EPMC8621886 | biostudies-literature
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