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ProteomicsThanatin Targets the Inter-Membrane Protein Complex Required for Lipopolysaccharide Transport in Escherichia coli
With the increasing resistance of many Gram-negative bacteria to existing classes of antibiotics, identifying new paradigms in antimicrobial discovery is an important research priority. Of special interest here are the proteins required for the biogenesis of the symmetric Gram-negative bacterial out...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084897 | MassIVE
ProteomicsThanatin Targets the Inter-Membrane Protein Complex Required for Lipopolysaccharide Transport in Escherichia coli
With the increasing resistance of many Gram-negative bacteria to existing classes of antibiotics, identifying new paradigms in antimicrobial discovery is an important research priority. Of special interest here are the proteins required for the biogenesis of the symmetric Gram-negative bacterial out...
ORGANISM(S): Escherichia coli 
2019-01-23 | PXD010988 | Pride
Photoaffinity labeling Thermo q-exactive plus Macrocyclic peptidomimetic antibiotics Interaction mapping Lpt complex Photo crosslinking Gram-negative eskape pathogens Molecular mode of action E.coli Dda Ompta (outer membrane-targeting antibiotics) Lc-ms/ms 
TranscriptomicsTime-resolved transcriptomic analysis reveals envelope stress–mediated adaptation of Escherichia coli to the LPS transport inhibitor thanatin
Gram-negative bacteria are a major cause of antibiotic-resistant infections due to their highly impermeable cell envelope which contains lipopolysaccharide (LPS) and prevents antibiotics from entering the cell. LPS biogenesis relies on the activity of the essential LPS transport machinery (Lpt), whi...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2026-09-10 | GSE271942 | GEO
ProteomicsDynamics of an LPS translocon induced by substrate and an antimicrobial peptide
We investigated the conformational dynamics of the LPS translocon LptDE was using hydrogen-deuterium exchange mass spectrometry. We evaluated the conformational changes of LptDE upon binding of LPS, Re-LPS (an LPS substructure), thanatin, and the membrane lipid POPG. Our data reveal that LPS induces...
ORGANISM(S): Klebsiella pneumoniae 
2020-11-16 | PXD021743 | Pride
Lps Hydrogen-deuterium exchange Hdx-ms Thanatin Lptde 
GenomicsTime-resolved transcriptomic analysis reveals envelope stress–mediated adaptation of Escherichia coli to the LPS transport inhibitor thanatin
Time-resolved transcriptomic analysis reveals envelope stress–mediated adaptation of Escherichia coli to the LPS transport inhibitor thanatin
PRJNA1134163 | ENA
UnknownThanatin: An Emerging Host Defense Antimicrobial Peptide with Multiple Modes of Action.
Not available
S-EPMC7913509 | biostudies-literature
UnknownEffects of Peptide Thanatin on the Growth and Transcriptome of Penicillium digitatum.
Not available
S-EPMC7767931 | biostudies-literature
UnknownBioengineering the Antimicrobial Activity of Yeast by Recombinant Thanatin Production.
Not available
S-EPMC10741026 | biostudies-literature
UnknownOuter-Membrane Permeabilization, LPS Transport Inhibition: Activity, Interactions, and Structures of Thanatin Derived Antimicrobial Peptides.
Not available
S-EPMC10888688 | biostudies-literature
UnknownThanatin and vinyl sulfide analogues as narrow spectrum antimicrobial peptides that synergise with polymyxin B.
Not available
S-EPMC11573584 | biostudies-literature
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