Sort   by:  
 Page size 
TranscriptomicsDecreased TFR/TFH ratio in SIV-infected rhesus macaques may contribute to accumulation of TFH cells in chronic infection
T follicular helper cells (TFH) are critical for the development and maintenance of germinal centers (GC) and humoral immune responses. During chronic HIV/SIV infection TFH accumulate, possibly as a result of antigen persistence. The HIV/SIV-associated TFH expansion may also reflect lack of regulati...
ORGANISM(S): Macaca mulatta 
2015-09-02 | E-GEOD-69756 | biostudies-arrayexpress
TranscriptomicsCataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pigtail Macaques
Our earlier studies in pig-tailed macaques demonstrated varying SHIV susceptibility during the menstrual cycle, likely caused by cyclic variations in immune responses in the female genital tract. There is concern that high-dose, long-lasting, injectable progestin-based contraception could mimic the...
ORGANISM(S): Macaca nemestrina 
2015-07-08 | E-GEOD-68079 | biostudies-arrayexpress
TranscriptomicsCytokine-independent detection of antigen-specific germinal center T follicular helper (Tfh) cells in immunized non-human primates using a live cell Activation Induced Marker (AIM) technique
A range of current candidate AIDS vaccine regimens are focused on generating protective HIV neutralizing antibody responses. Many of these efforts rely on the rhesus macaque animal model. Understanding how protective antibody responses develop and how to increase their efficacy are both major knowle...
ORGANISM(S): Macaca mulatta 
2016-09-07 | E-GEOD-81382 | biostudies-arrayexpress
TranscriptomicsGene expression profiling data from sooty mangabeys treated with interferon alpha
In contrast to pathogenic HIV and SIV infection of humans and macaques, SIV infection of sooty mangabeys (SMs) is typically non-pathogenic despite high virus replication. A key feature of primary SIV infection of SMs is a strong type I interferon (IFN-I) response, characterized by massive up-regulat...
ORGANISM(S): Cercocebus atys 
2012-07-09 | E-GEOD-35460 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of experimental CD8+ lymphocyte depletion in rhesus macaques infected with SIVmac239
CD8+ T-cells inhibit virus replication in SIV-infected rhesus macaques (RM). However, it is unclear to what extent the viral suppression mediated by CD8+ T-cells reflects direct killing of infected cells as opposed to indirect, non-cytolytic mechanisms. In this study, we used functional genomics to ...
ORGANISM(S): Macaca mulatta 
2013-02-08 | E-GEOD-37834 | biostudies-arrayexpress
TranscriptomicsACTG A5258 Clinical administration of chloroquine to patients with untreated chronic HIV infection to reduce immune activation
ACTG A5258, we asked whether chloroquine could reduce the immune activation in HIV infection posited to be driven by microbial TLR agonists, such as bacterial elements translocated from the gut and HIV-1 RNAs . We anticipate that blocking this activation pathway might interfere with events in patho...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-71063 | biostudies-arrayexpress
TranscriptomicsACTG A5258 Clinical administration of chloroquine to HIV-infected patients receiving antiretroviral therapy to reduce immune activation
ACTG A5258, we asked whether chloroquine could reduce the immune activation in HIV infection posited to be driven by microbial TLR agonists, such as bacterial elements translocated from the gut and HIV-1 RNAs . We anticipate that blocking this activation pathway might interfere with events in patho...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-71064 | biostudies-arrayexpress
TranscriptomicsType I IFN responses in rhesus macaques prevent SIV transmission and slow disease progression
In acute HIV infection immune activation may provide target cells and drive virus replication, which innate immunity may limit. Thus, the net effects of inflammatory mediators, including type I interferon (IFN-I), are unclear. Here, we block IFN-I signaling during pathogenic acute SIV infection wit...
ORGANISM(S): Macaca mulatta 
2014-07-23 | E-GEOD-53690 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiles of cardiac progenitors differentiated from human pluripotent stem cells in 3D culture under simulated microgravity
Methods: RNA-seq libraries were prepared using the Illumina TruSeq RNA kit and the TrueSeq method was employed for mRNA enrichment. The libraries were quantified and samples were multiplexed in each lane of the flowcell. Cluster generation was performed and then sequenced on the Illumina HiSeq1000 s...
ORGANISM(S): Homo sapiens 
2016-08-08 | E-GEOD-84582 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of rhesus macaques vaccinated with ALVAC-SIVgpe DNA + SIVgp120 protein subunit and unvaccinated controls after challenge with SIVmac251 - 3 wks post-infection
The SIVmac251 macaque model has been used to evaluate the efficacy of vaccine for HIV. Exposure of macaques to a single high dose of SIVmac251 results in transmission of multiple viral variants, which contrasts the few HIV variants typically transmitted in humans. In here, we investigated whether th...
ORGANISM(S): Macaca mulatta 
2013-03-01 | E-GEOD-37311 | biostudies-arrayexpress
Sort   by:  
 Page size