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ProteomicsBS3 crosslinking of the Anaphase-Promoting Complex/Cyclosome (APC/C)
In order to investigate the dynamic regulation of the APC/C by intrinsically disordered regions (IDRs) upon phosphorylation, we employed cross-linking mass spectrometry (CLMS). Given that the phosphorylation of Apc1-300L (IDR in Apc1) is a key determinant in its release from the co-activator binding...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2024-04-23 | PXD050097 | Pride
Crosslinking mass spectrometry The anaphase-promoting complex/cyclosome (apc/c) 
ProteomicsCDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway by affecting the UFL1 ubiquitination.
DNA double-strand breaks (DSBs) contribute to genome instability, a key feature of cancer. DSBs are mainly repaired by homologous recombination (HR) and non-homologous end-joining (NHEJ). We investigated the role of an isoform of the multifunctional cyclin-dependent kinase 9, CDK9-55, in DNA repair,...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-20 | MSV000087856 | MassIVE
TranscriptomicsB-catenin deficiency, but not c-Myc deletion, suppresses the immediate phenotypes of Apc loss in the liver
Dysregulated Wnt signalling is seen in approximately 30% of hepatocellular cancers, thus finding pathways downstream of activation of Wnt signalling is key. Using cre lox technology we have deleted the the adenomatous polyposis coli tumour suppressor protein (Apc) within the adult mouse liver and ob...
ORGANISM(S): Mus musculus 
2015-01-31 | E-GEOD-65476 | biostudies-arrayexpress
UnknownVisualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).
Not available
S-EPMC5717348 | biostudies-literature
UnknownA minimal anaphase promoting complex/cyclosome (APC/C) in Trypanosoma brucei.
Not available
S-EPMC3606461 | biostudies-literature
GenomicspiRNA-independent Function of PIWIL1 as a Novel co-activator for Anaphase Promoting Complex/Cyclosome (APC/C) to Drive Pancreatic Cancer Metastasis
piRNA-independent Function of PIWIL1 as a Novel co-activator for Anaphase Promoting Complex/Cyclosome (APC/C) to Drive Pancreatic Cancer Metastasis
PRJNA593186 | ENA
UnknownTargeting the anaphase-promoting complex/cyclosome (APC/C)- bromodomain containing 7 (BRD7) pathway for human osteosarcoma.
Not available
S-EPMC4102794 | biostudies-literature
GenomicsThe Anaphase Promoting Complex/Cyclosome degrades DMS3 to maintain RNA-directed DNA Methylation in Arabidopsis [lncRNA-seq]
The Anaphase Promoting Complex/Cyclosome degrades DMS3 to maintain RNA-directed DNA Methylation in Arabidopsis [lncRNA-seq]
PRJNA418706 | ENA
GenomicsThe Anaphase Promoting Complex/Cyclosome degrades DMS3 to maintain RNA-directed DNA Methylation in Arabidopsis [small RNA-seq]
The Anaphase Promoting Complex/Cyclosome degrades DMS3 to maintain RNA-directed DNA Methylation in Arabidopsis [small RNA-seq]
PRJNA418705 | ENA
GenomicspiRNA-independent Function of PIWIL1 as a Novel co-activator for Anaphase Promoting Complex/Cyclosome (APC/C) to Drive Pancreatic Cancer Metastasis
Piwi proteins are normally restricted in germ cells to suppress transposons through association with piRNAs, but are also frequently activated in many types of human cancers. Of great puzzle is the lack of induction of corresponding piRNAs in cancer cells, as we document here in human pancreatic duc...
ORGANISM(S): Homo sapiens Mus musculus 
2020-02-01 | GSE141340 | GEO
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