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TranscriptomicsCharacterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling
The activation of the transcription factor NF-E2-related factor 2 (Nrf2) maintains cellular homeostasis in response to oxidative stress by the regulation of multiple cytoprotective genes. Without stressors the activity of Nrf2 is inhibited by its interaction with the kelch-like ECH-associated protei...
ORGANISM(S): Mus musculus 
2015-10-31 | E-GEOD-71695 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Keap1-null (CKO) to investigate genetic and pharmacologic activation of Nrf2 signaling
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct hepatic gene expression profiles between Keap1 knockout and triterpenoid treated mice; Loss of Nrf2 signaling increases susceptibility to acute toxicity, inflammation, and carcinogenesis in mice due to the inabilit...
ORGANISM(S): Mus musculus 
2009-05-11 | E-GEOD-15633 | biostudies-arrayexpress
TranscriptomicsWhole esophagi of WT, Nrf2-/- and Keap1-/- mice on C57BL background at E11.5, E15.5, P0 and P7, and esophageal epithelium of adult (8 weeks old) mice
Transcriptional profiling of mouse esophageal development. Goal was to globally profile critical genes and signaling pathways during the development of mouse esophagus and determine how Nrf2/Keap1 pathway regulates the morphogenesis of the esophageal epithelium. Mutiple-comparison. WT-E11.5 vs. WT-E...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-34278 | biostudies-arrayexpress
GenomicsFGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice
FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice
PRJNA1011247 | ENA
GenomicsChemical Modulation of Glycolysis Regulates the KEAP1-NRF2 Pathway Through a Metabolite-Induced Posttranslational Modification
Chemical Modulation of Glycolysis Regulates the KEAP1-NRF2 Pathway Through a Metabolite-Induced Posttranslational Modification
PRJNA479768 | ENA
UnknownThe KEAP1/NRF2 Signaling Pathway in Keratinization.
Not available
S-EPMC7465315 | biostudies-literature
GenomicsThe Keap1-Nrf2-Bach1 signaling mediates UBR7 negative regulation of HK2 to inhibit glycolysis and HCC tumorigenesis
The Keap1-Nrf2-Bach1 signaling mediates UBR7 negative regulation of HK2 to inhibit glycolysis and HCC tumorigenesis
PRJNA725561 | ENA
UnknownInhibition of the Keap1/Nrf2 Signaling Pathway Significantly Promotes the Progression of Type 1 Diabetes Mellitus.
Not available
S-EPMC7884168 | biostudies-literature
UnknownThe Keap1/Nrf2 Signaling Pathway in the Thyroid-2020 Update.
Not available
S-EPMC7693470 | biostudies-literature
UnknownCurcumin induces ferroptosis in hepatocellular carcinoma by regulating the P62-KEAP1-NRF2-signaling pathway.
Not available
S-EPMC12822296 | biostudies-literature
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