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TranscriptomicsTranscription profiling of mouse Podocytes reveal use of FcRn to clear IgG from the glomerular basement membrane
The glomerular filtration barrier prevents large serum proteins from being lost into the urine. It is not known, however, why the filter does not routinely clog with large proteins that enter the glomerular basement membrane (GBM). Here we provide evidence that an active transport mechanism exists t...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10017 | biostudies-arrayexpress
UnknownThe neonatal Fc receptor, FcRn, as a target for drug delivery and therapy.
Not available
S-EPMC4544678 | biostudies-literature
UnknownThe neonatal Fc receptor (FcRn) is a pan-arterivirus receptor.
Not available
S-EPMC11306234 | biostudies-literature
UnknownTissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice.
Not available
S-EPMC4968098 | biostudies-literature
ProteomicsThe C-terminal end of engineered albumin variants and fusion proteins after exposure to carboxypeptidase A
Albumin has a long plasma half-life due to engagement of the neonatal Fc receptor (FcRn), which prevents intracellular degradation. However, its C-terminal end can be cleaved by carboxypeptidase A, and removal of the last leucine residue (L585) weakens receptor binding, reducing its half-life from 2...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-19 | PXD063561 | Pride
Albumin engineering Carboxypeptidase a The neonatal fc receptor (fcrn) Albumin-fusion proteins 
UnknownReducing IgG accumulation via neonatal Fc receptor (FcRn) blockade relieves neuropathic pain.
Not available
S-EPMC11903150 | biostudies-literature
UnknownLeveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier.
Not available
S-EPMC12049489 | biostudies-literature
ProteomicsInvestigation of the FcRn:IgG interaction by HDX-MS
Immunoglobulin Gs (IgGs) have become highly successful drug scaffolds by combining very specific target binding with the ability to induce cellular cytotoxicity. Of further advantage, IgGs possess unusually long half-lives in the blood (2-3 week). IgGs achieve such extraordinary half-lives through a...
ORGANISM(S): Homo sapiens (Human) 
2024-12-02 | PXD044285 | Pride
Ms  protein-protein interaction  mass spectrometry Hdx-ms 
UnknownClinical ramifications of the MHC family Fc receptor FcRn.
Not available
S-EPMC3069705 | biostudies-literature
UnknownX-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn.
Not available
S-EPMC2934637 | biostudies-literature
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