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ModelsSeptation Initiation Network
The Septation Initiation Network (SIN) controls cytokinesis in fission yeast. This model uses CDK activity levels as control nodes to simutate SIN related events throughout different stages of the cell cycle. This model was optimized using single knock-out experiments and has made in silico predicti...
4705 | Cell Collective
MetabolomicsMetabolomic Profiling Following Sin A Treatment

Schisantherin A, a natural product, safely alleviates obesity and associated metabolic disorders by orchestrating crosstalk among immune, neuronal, adipose cells, metabolic organs, and gut bacteria via increased circulating conjugated bile acids.

2025-11-21 | MTBLS13266 | MetaboLights
ProteomicsInducible gene deletion reveals essentiality of protein kinases and a septation initiation network in Candida albicans
Protein kinases are key components of many signaling pathways that regulate cellular activities, and some of them are indispensable for the viability of cells. We used inducible gene deletion to assess the importance of a set of putative essential protein kinases for growth and viability of the path...
ORGANISM(S): Candida albicans (Yeast) 
2026-04-14 | PXD070087 | Pride
Candida albicans Kinase mutants Septation initiation network Auxin-induced protein depletion 
ProteomicsA new identified suppressor of Cdc7p/SepH kinase, PomA, regulates fungal asexual reproduction via affecting phosphorylation of MAPK-HogA
The septation initiation network (SIN), composed of a conserved SepH (Cdc7p) kinase cascade, plays an essential role in fungal cytokinesis/septation and conidiation for asexual reproduction, while the mitogen-activated protein kinase (MAPK) pathway depends on successive signaling cascade phosphoryla...
ORGANISM(S): Emericella nidulans (Aspergillus nidulans) 
2019-06-17 | PXD012514 | Pride
The septation initiation network (sin) Aspergillus nidulans The mitogen-activated protein kinase (mapk) Poma 
UnknownLoss of Septation Initiation Network (SIN) kinases blocks tissue invasion and unlocks echinocandin cidal activity against Aspergillus fumigatus.
Not available
S-EPMC8376064 | biostudies-literature
UnknownMOB-mediated regulation of septation initiation network (SIN) signaling is required for echinocandin-induced hyperseptation in Aspergillus fumigatus.
Not available
S-EPMC10964416 | biostudies-literature
UnknownPhospho-regulation of the Neurospora crassa septation initiation network.
Not available
S-EPMC3804505 | biostudies-literature
UnknownCdk1 promotes cytokinesis in fission yeast through activation of the septation initiation network.
Not available
S-EPMC4116299 | biostudies-literature
UnknownThe nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission yeast.
Not available
S-EPMC1949376 | biostudies-literature
UnknownPpc89 links multiple proteins, including the septation initiation network, to the core of the fission yeast spindle-pole body.
Not available
S-EPMC1593159 | biostudies-literature
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