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TranscriptomicsTime-series of IL-6 stimulated primary mouse hepatocytes
External stimulations of cells by hormones, growth factors or cytokines activate signal transduction pathways that subsequently induce a rearrangement of cellular gene expression. The representation and analysis of changes in the gene response is complicated, and essentially consists of multiple lay...
ORGANISM(S): Mus musculus 
2010-04-07 | E-GEOD-21031 | biostudies-arrayexpress
TranscriptomicsQuantification of regenerative potential in primary human mammary epithelial cells
We present an organoid regeneration assay in which freshly dissociated human mammary epithelial cells from healthy donors are grown in adherent/rigid or floating/compliant collagen I gels. In both conditions, luminal progenitors (CD49f+EpCAM+) form spheres, whereas basal cells (CD49fhiEpCAM-) genera...
ORGANISM(S): Homo sapiens 
2015-07-02 | E-GEOD-64248 | biostudies-arrayexpress
GenomicsHigh-throughput single cell gene expression analysis in primary blood stem and progenitor cells identifies new links between key transcriptional regulators
Cellular decision-making is mediated by a complex interplay of external stimuli with the intracellular environment, in particular transcription factor regulatory networks. Here we have determined the expression of a network of 18 key haematopoietic transcription factors (TFs) in 597 single primary ...
ORGANISM(S): Mus musculus 
2013-04-24 | E-GEOD-42518 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-IBIOS-01-06-2015-13:43:18:542-193 - samples
Whole Genome Sequencing of Huh7 cell lines
EGAD00001001386 | EGA
GenomicsEngineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus
Short hairpin RNA (shRNA) expression strategies that allow safe and persistent target mRNA knockdown are key to the success of many in vitro or in vivo RNAi applications. Here, we propose a novel solution which is expression of a promoterless miRNA-adapted shRNA (shmiRNA) from an engineered genomic ...
EGAS00001001252 | EGA
GenomicsBioinformatics of Data Analysis (B240)
Data Access Committee EGAC00001000346
EGAC00001000346 | EGA
TranscriptomicsIL13_0-12h_RAIA_et_al
Primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) share a frequent constitutive activation of Janus-activated kinase (JAK) / signal transducer and activator of transcription (STAT) signaling pathway. Due to complex non-linear relations within the pathway, key dynamic pr...
ORGANISM(S): Homo sapiens 
2010-12-09 | E-GEOD-23591 | biostudies-arrayexpress
ModelsRaia2011 - IL13 L1236
This is the model of IL13 induced signalling in L1236 cells described in the article: Dynamic Mathematical Modeling of IL13-Induced Signaling in Hodgkin and Primary Mediastinal B-Cell Lymphoma Allows Prediction of Therapeutic Targets. Raia V, Schillin...
2024-09-02 | BIOMD0000000314 | BioModels
ModelsRaia2010 - IL13 Signalling MedB1
This is the model of IL13 induced signalling in MedB-1 cell described in the article: Dynamic Mathematical Modeling of IL13-Induced Signaling in Hodgkin and Primary Mediastinal B-Cell Lymphoma Allows Prediction of Therapeutic Targets. Raia V, Schilling M, Böhm M, Hahn B, Kowarsch A,...
2024-09-02 | BIOMD0000000313 | BioModels
TranscriptomicsFLASH-seq analysis of adipocyte precursor subpopulations (P1 and P2) isolated from a high-fat diet (HFD) mouse, comparing two sorting strategies: conventional manual gating and ConvexGating
This experiment evaluates whether the gates predicted by the tool ConvexGating improve the isolation of adipocyte precursor subpopulations (P1 and P2) from one high-fat diet (HFD) mouse relative to conventional manual gating. Visceral white adipose tissue (WAT) was chosen as a challenging test case ...
ORGANISM(S): Mus musculus 
2026-07-17 | E-MTAB-17301 | biostudies-arrayexpress
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