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TranscriptomicsAnalysis of temporal mRNA expression changes in cultured keratinocytes from Casp-8F/M-bM-^@M-^SK5-Cre and Casp-8F/+K5-Cre mice
Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of NF-kB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not de...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17345 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile comparison of M. tuberculosis PDIM spontaneous mutants
Transcriptional profile comparison among PDIM positive and negative isolates. Standard in vitro exponential phase cultures of M. tuberculosis H37Rv ATCC27294 were plated on 7H11 plates. Individual colonies were sub-cultured in 7H9 broth and metabolically labeled with [14C] propionic acid. The apolar...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-16 | E-GEOD-17234 | biostudies-arrayexpress
TranscriptomicsGenomic comparison of M. tuberculosis PDIM spontaneous mutants
Genomic comparisons among PDIM positive and negative isolates. Standard in vitro exponential phase cultures of M. tuberculosis H37Rv ATCC27294 were plated on 7H11 plates. Individual colonies were sub-cultured in 7H9 broth and metabolically labeled with [14C] propionic acid. The apolar lipid fraction...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-16 | E-GEOD-17232 | biostudies-arrayexpress
TranscriptomicsMap transformed DNA into W6G from VCXB21
Vibrio cholerae isolate W6G transformed with DNA from VCXB21 and selected for chitosan metabolism. Nine independent transformants compared to parental W6G on microarrays containing probes for all N16961 ORFs. Regions acquired from VCXB21 hybridize more strongly to the array. A genotyping experimen...
ORGANISM(S): Vibrio cholerae 
2007-08-16 | E-GEOD-8791 | biostudies-arrayexpress
TranscriptomicsHepatocellular carcinomas (HCC) in mice transduced in utero with feline immunodeficiency virus-based vectors (CGH)
Fetal mice (16 days gestation) were administered FIV-based lentiviral viral particles containing the gene encoding EGFP. Six liver tumors developed in three mice (1 male, 2 females) between the ages of 273 and 484 days, each mouse developed 2 tumors. These tumors and non-tumorous liver tissue from ...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-25900 | biostudies-arrayexpress
TranscriptomicsPTEN loss deM-oM-,M-^Anes a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) represents a heterogeneous diagnostic category with distinct molecular subtypes that can be deM-oM-,M-^Aned by gene expression proM-oM-,M-^Aling. However, even within these deM-oM-,M-^Aned subtypes, heterogeneity prevails. To further elucidate the pathogenesis o...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-45495 | biostudies-arrayexpress
TranscriptomicsHepatocellular carcinomas (HCC) in mice transduced in utero with feline immunodeficiency virus-based vectors (expression)
Fetal mice (16 days gestation) were administered feline immunodeficiency virus (FIV)-based lentiviral viral particles containing the gene encoding GFP. Six liver tumors developed in three mice between the ages of 273 and 484 days, each mouse developed 2 tumors. These tumors and non-tumorous liver t...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-19306 | biostudies-arrayexpress
TranscriptomicsM. sedula transcriptional response under "strict" carbon-limited autotrophy compared to carbon "rich" autotrophy and heterotrophy
Metallosphaera sedula is an extremely thermoacidophilic archaeon that grows heterotrophically on peptides, and chemolithoautotrophically on hydrogen, sulfur, or reduced metals as energy sources. During autotrophic growth, carbon dioxide is incorporated into cellular carbon via the 3-hydroxypropionat...
ORGANISM(S): Metallosphaera sedula DSM 5348 
2013-03-05 | E-GEOD-39944 | biostudies-arrayexpress
TranscriptomicsArray-Based Genomic Comparative Hybridization Analysis of Field Strains of Mycoplasma hyopneumoniae
Mycoplasma hyopneumoniae is the causative agent of porcine enzootic pneumonia and a major factor in the porcine respiratory disease complex. A clear understanding of the mechanisms of pathogenesis does not exist although it is clear that M. hyopneumoniae adheres to porcine ciliated epithelium by act...
ORGANISM(S): Mycoplasma hyopneumoniae 
2010-05-27 | E-GEOD-8306 | biostudies-arrayexpress
TranscriptomicsThe Pitx2:miR-200c/141:noggin pathway regulates BMP signaling and ameloblast differentiation
The mouse incisor is a remarkable tooth that grows throughout the animalM-bM-^@M-^Ys lifetime. This continuous renewal is fueled by epithelial stem cells that give rise to ameloblasts, which generate enamel, and little is known about the function of specific miRNAs in this process. Here we describe ...
ORGANISM(S): Mus musculus 
2013-07-09 | E-GEOD-48583 | biostudies-arrayexpress
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