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MetabolomicsThe Poly (ADP-Ribose) Polymerase inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells
Breast tumors are characterized into different subtypes based on their surface marker expression, which affects their prognosis and treatment. For example, triple negative breast cancer cells (ER-/PR-/Her2-) show reduced susceptibility towards radiotherapy and chemotherapeutic agents. Poly (ADP-ribo...
2016-11-07 | MTBLS337 | MetaboLights
MetabolomicsBerberine alleviates radiation-induced lung injury through promoting microbiota-derived inosine via gut-lung axis

Radiation-induced lung injury (RILI) is a major complication of thoracic radiotherapy. A previous study has indicated an association between berberine (BBR) and reduced incidence of RILI. However, the underlying mechanisms remain unknown. Here we validated the radioprotective role of BBR in mouse...

2025-05-14 | MTBLS12391 | MetaboLights
MetabolomicsMechanism of Blueberry Anthocyanins in Ameliorating Radiation-Induced Intestinal Injury through Gut Microbiota Modulation
Radiation-induced intestinal injury denotes structural and functional impairment of the intestines resulting directly or indirectly from ionising radiation, such as that employed in radiation therapy for malignant tumours in the abdominal or pelvic regions, within the treatment area. It is a prevale...
2026-05-29 | MTBLS14609 | MetaboLights
MetabolomicsSIRT5 alleviate cardiomyocyte senescence in radiation-induced heart disease via desuccinylation of HADHB

SIRT5 deficiency caused widespread protein hypersuccinylation in cardiac tissue. Succinylation proteomic analysis revealed HADHB as the key SIRT5 target, with lysine 292 (K292) being the dominant succinylation site. Functional studies demonstrated that K292 succinylation impairs HADHB-mediated fa...

2026-03-15 | MTBLS14057 | MetaboLights
TranscriptomicsExposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland
Six to eight week old female C57BL/6J mice were exposed to 2 Gy of whole body γ radiation and mammary glands were surgically removed 2-month after radiation. RNA was isolated and microarray hybridization performed for gene expression analysis. 5 samples were analyzed: 2 controls at 2 months, 1 2 Gy ...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-57196 | biostudies-arrayexpress
TranscriptomicsSenescence gene signature of radiation fibrosis
Radiation lung injury is characterized by early inflammation and late fibrosis. The causes underlying the chronic, progressive nature of radiation injury are poorly understood. Here, we report that the gene expression of irradiated lung tissue correlates with that observed in the lungs in aged anim...
ORGANISM(S): Mus musculus 
2013-11-01 | E-GEOD-41789 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Norwegian spruce embryos exposed to gamma radiation
Conifers such as Picea abies (Norway spruce) are among the most radiosensitive plant species, yet the molecular impact of ionising radiation on their stem cells remains poorly understood. This study examines the transcriptomic response of embryogenic stem cells to gamma radiation, focusing on mechan...
ORGANISM(S): Picea abies 
2025-07-14 | E-MTAB-15297 | biostudies-arrayexpress
MetabolomicsMutations-Upstream-of-Metabolomic-Signature Based Functional Analyses Identify Prognostic Biomarkers and Therapeutic Targets in Pancreatic Ductal Adenocarcinoma

Cross-talk among downstream regulatory networks of genome mutations has been the major hypothetical mechanism underlying poor prognosis and low-responsive rates for targeted therapy of pancreatic ductal adenocarcinoma (PDAC). By applying a causal inference-based mutation-upstream-of-the-metabolom...

2025-10-13 | MTBLS13111 | MetaboLights
ProteomicsInhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair
Glioblastoma (GBM) is the most lethal brain tumour that occurs in adults and treatment for GBM has been largely unsuccessful. Ionizing radiation (IR) and chemotherapeutic agents are employed as standard of care treatment for GBM patients and both result in DNA damage. Previous data identified phosph...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-08-07 | MSV000081423 | MassIVE
TranscriptomicsGene expression response to high radiation treatment in MCF7 breast cancer cell line
Intraoperative radiotherapy (IOERT) is a high radiation therapeutic technique which administers a single high dose of ionizing radiation (IR) immediately after surgical tumor removal in order to destroy the residual cancer cells in the site at high risk for recurrence. IR is able to regulate several...
ORGANISM(S): Homo sapiens 
2015-06-11 | E-GEOD-63667 | biostudies-arrayexpress
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