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ProteomicsFFPE tumor samples reveals the influences of NET-1 siRNA nanoparticles and sonodynamic therapy on tetraspanin protein involved in HCC
Hepatocellular carcinoma (HCC) poses a severe threat to human health. The NET-1 protein has been proved to be strongly associated with HCC proliferation and metastasis in our previous study. Here, we established and validated NET-1 siRNA nanoparticles system to conduct targeted gene therapy of HCC x...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020763 | Pride
Ultrasound Proteomics Mass spectrometry Tetraspanin protein Hepatocellular carcinoma Sonodynamic therapy 
ProteomicsEpi-proteomic assessment of backpain therapy
This study investigates how molecular profiles evolve in response to standardized sport therapy and non-controlled lifestyle choices. We report that the therapy improves agility, attenuates backpain, and also triggers healthier habits. We find that a subset of participants´ histone methylation and a...
ORGANISM(S): Homo sapiens (Human) 
2024-10-21 | PXD050113 | Pride
Pbmc Histone ptms Buccal swabs Proteome Backpain therapy 
TranscriptomicsGene expression changes associated with resistance to intravenous corticosteroid therapy in children with severe ulcerative colitis
Although corticosteroids remain a mainstay of therapy for UC, a meta-regression of cohort studies in acute severe ulcerative colitis (UC) showed that 29% of patients fail corticosteroid therapy and require escalation of medical management or colectomy. We aimed to determine whether genes expressed i...
ORGANISM(S): Homo sapiens 
2010-08-31 | E-GEOD-21231 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in RA synovial biopsies from responders versus non-responders to adalimumab therapy
TNF antagonists are routinely used in severe rheumatoid arthritis (RA) patients who failed conventional DMARD therapy. According to large clinical trials, the three available drugs (adalimumab, infliximab and etanercept) display similar effects in terms of efficacy, tolerability and side effects. Th...
ORGANISM(S): Homo sapiens 
2009-04-15 | E-GEOD-15602 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of PBMCs from HCC patients pre- and post-curative therapy
This dataset contains processed single-cell RNA sequencing (scRNA-seq) data from peripheral blood mononuclear cells (PBMCs) collected from six hepatocellular carcinoma (HCC) patients, before and after curative therapy. Samples were profiled using the 10x Genomics Chromium platform. The dataset inclu...
ORGANISM(S): Homo sapiens 
2026-01-13 | E-MTAB-16408 | biostudies-arrayexpress
MetabolomicsFetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants
Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress, skewing the cell’s...
2018-06-06 | MTBLS449 | MetaboLights
UnknownInterventions for Breast Cancer-Related Lymphedema: Clinical Practice Guideline From the Academy of Oncologic Physical Therapy of APTA.
Not available
S-EPMC7412854 | biostudies-literature
TranscriptomicsPredicting response to vedolizumab therapy using mucosal transcriptomics in IBD patients
In this study we wanted to identify baseline predictors of successful vedolizumab therapy in patients with inflammatory bowel disease.
ORGANISM(S): Homo sapiens 
2019-08-23 | E-MTAB-7845 | biostudies-arrayexpress
UnknownPhysical Therapist Management of Parkinson Disease: A Clinical Practice Guideline From the American Physical Therapy Association.
Not available
S-EPMC9046970 | biostudies-literature
UnknownPhysical Therapist Management of Total Knee Arthroplasty.
Not available
S-EPMC7462050 | biostudies-literature
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