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TranscriptomicsTranscription profiling of rat Postnatal developmental changes in Sprague-Dawley animals in the model of neuropathic pain - spare nerve injury
Neuropathic pain is an apparently spontaneous experience triggered by abnormal physiology of the peripheral or central nervous system, which evolves with time. Neuropathic pain arising from peripheral nerve injury is characterized by a combination of spontaneous pain, hyperalgesia and allodynia. The...
ORGANISM(S): Rattus norvegicus 
2010-01-30 | E-GEOD-15041 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling of post-injury and uninjured mouse lung neutrophils from a thermal injury model
Lungs were collected as soon as possible after thermal injury 30-40 mins post injury for neutrophil isolation. Lungs were minced in HBSS with 1% BSA (Sigma) and strained through a 40um nylon filter (BD). Samples were sorted using BD fusion machine. A 100um nozzle was used at a flow rate of 2.RNA wa...
ORGANISM(S): Mus musculus 
2020-11-13 | E-MTAB-9770 | biostudies-arrayexpress
TranscriptomicstrkB.T1 WT versus trkB.T1 KO expression data following spinal cord injury (SCI)
We profiled spinal cord tissue at the site of a moderate contusion injury at the level of the thoracic spinal cord We examined several timepoints following injury, including sham and days 1,3 and 7 following injury and compared differential expression of genes within a genotype and across genotypes ...
ORGANISM(S): Mus musculus 
2013-08-05 | E-GEOD-47681 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat liver after long term thermal injury
These samples comprise the full analysis of liver function during response to thermal injury. Experiment Overall Design: - 4 analysis days Experiment Overall Design: - three samples per day Experiment Overall Design: - burn (experimental) Experiment Overall Design: - sham (control) Experiment Ov...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5647 | biostudies-arrayexpress
TranscriptomicsLong Term Thermal Injury Analysis
These samples comprise the full analysis of liver function during response to thermal injury. Keywords: Time Course
ORGANISM(S): Rattus norvegicus 
2006-08-30 | GSE5647 | GEO
ProteomicsTemporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice.
Introduction Severe injury, including burn trauma, leads to profound immune dysfunction, yet the mechanisms driving these changes remain incompletely defined. This lack of understanding has hindered efforts to modulate the immune response effectively. Additionally, a clear biomarker profile to guide...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-21 | PXD062615 | Pride
Protein cargo Extracellular vesicles Macrophages Burn injury Thermal injury Burn injury 
TranscriptomicsTranscription profiling of skin excised from thermal injured mouse to investigate the molecular mechanism of murine dermal burn wound.
Investigation into murine dermal burn wound. Mouse thermal injury induced, and skin excised at 0 hours, 2 hours, 3 days and 14 days post-injury. Transcription profiling of skin excised from thermal injured mouse to investigate the molecular mechanism of murine dermal burn wound.
ORGANISM(S): Mus musculus 
2007-11-07 | E-GEOD-460 | biostudies-arrayexpress
TranscriptomicsAcute and chronic liver injury change the small RNA cargoes carried by serum small extracellular vesicles in mice
Compared to whole serum miRNAs, miRNAs in serum small extracellular vesicles (sEVs) are well protected form RNA enzymes, thus provide a consistent source of miRNA for disease biomarker detection. Serum sEVs and their miRNA cargos released by injured liver cells could be promising biomarkers for diag...
ORGANISM(S): Mus musculus 
2021-08-07 | E-MTAB-9462 | biostudies-arrayexpress
GenomicsMus musculus strain:C57BL/6N
Thermal-induced Spinal Cord Injury
PRJDB40340 | ENA
TranscriptomicsNociceptor HDAC4 regulates inflammatory pain
Transcriptional alterations are characteristic of persistent pain states but the key regulators remain elusive. Using a conditional knockout (cKO) strategy in mice we sought to determine whether loss of the transcriptional co-repressor histone deacetylase four (HDAC4) would have implications for sen...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-62405 | biostudies-arrayexpress
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