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MetabolomicsThermal Profiling Maps Multilayered Organization of the Mitochondrial Proteome

Mitochondria execute essential metabolic, biosynthetic, and signaling functions, yet the regulatory principles governing their proteome remain incompletely understood. Here, we develop a thermal proteome profiling (TPP) workflow applied directly to purified mitochondria, enabling systematic analy...

2025-12-08 | MTBLS7386 | MetaboLights
UnknownDeep thermal profiling for detection of functional proteoform groups.
Not available
S-EPMC10374440 | biostudies-literature
ProteomicsProteoform-level drug target landscapes demonstrates a wider spectrum of ibrutinib targets
In this study, we investigated the target landscape of the drug ibrutinib using thermal proteome profiling (TPP) and proteoform detection. Our findings demonstrated that ibrutinib interacts with multiple proteoforms, beyond its known targets. Specifically, we identified interactions related to immun...
ORGANISM(S): Homo sapiens (Human) 
2024-11-24 | PXD047187 | Pride
Acute lymphoblastic leukemia Ibrutinib Proteoforms Thermal proteoform profiling 
ProteomicsThermal proteome profiling of childhood ALL cell lines for proteoform detection
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and it has a 5-year survival rate of 85% for European children. But for subsets of patients who fail to respond to standard of care chemotherapeutics, treatment options are limited, and clinical prognosis is poor. To establish a...
ORGANISM(S): Homo sapiens (Human) 
2023-03-20 | PXD031162 | Pride
Proteoforms Tpp Cetsa Lc-msms All 
UnknownTop-Down Thermal Proteome Profiling (TD-TPP) for Functional Characterization of the Intact Proteoforms in Complex Samples.
Not available
S-EPMC12649780 | biostudies-literature
UnknownFunctional proteoform group deconvolution reveals a broader spectrum of ibrutinib off-targets.
Not available
S-EPMC11862126 | biostudies-literature
ProteomicsDeveloping a Novel and Integrative Method to Systematically Investigate the Stability of N-Terminal Proteoforms
Protein N-terminal proteoforms, which include both N-terminal modifications and sequence variation arising from processes such as proteolytic cleavage, are common in cells and have been reported to significantly impact protein stability. Systematically examining the correlation between these N-termi...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD057760 | Pride
Thermal proteome profiling N-terminal acetylation N-terminome Thermal stability difference Terminal amine isotopic labeling of substrates Tails Tpp N-terminal proteoform 
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