Sort   by:  
 Page size 
TranscriptomicsExpression profiling in dopaminergic brain structures of rats self-administering cocaine
Gene expression profiling in dopaminergic brain structures of rats self-administering cocaine. Effect of histone deacetylase inhibition We have shown that injection of the HDAC inhibitor trichostatin A (TsA) to rats is sufficient to decrease their motivation to self-administer cocaine. The aim of th...
ORGANISM(S): Rattus norvegicus 
2010-01-21 | E-GEOD-18055 | biostudies-arrayexpress
TranscriptomicsSOX2 overexpression effect on human lung squamous cells
We have identified SOX2 as a new oncogene and a likely driver of recurrent 3q26.3 amplifications in lung Squamous Cell Carcinoma. SOX2 is a crucial transcription factor implicated in Embryonic and Neural Stem Cells, that we found widely activatd in human lung SCC. This part of the study aimed at an...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-14883 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Pseudomonas aeruginosa of the sulfate starvation response
Gene expression in response to changes in sulfur supply was studied in P. aeruginosa E601, a cystic fibrosis isolate that displays mucin sulfatase activity, and in P. aeruginosa PAO1. A large family of genes was found to be upregulated by sulfate limitation in both isolates, encoding sulfatases and ...
ORGANISM(S): Pseudomonas aeruginosa 
2008-06-16 | E-GEOD-8408 | biostudies-arrayexpress
TranscriptomicsExpression profiles of the hippocampus of Rsk2-KO mice
Coffin–Lowry Syndrome (CLS) is a syndromic form of mental retardation caused by loss of function mutations in the X-linked RPS6KA3 gene, which encodes Rsk2, a serine/threonine kinase involved in spatial memory. We analyzed hippocampal gene expression profiles in Rsk2-KO mice to identify changes in ...
ORGANISM(S): Mus musculus 
2010-12-22 | E-GEOD-22137 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat lung alveolar development
Lung alveolarization is a complex process that involves interactions between several cell types and leads to considerable increase in gas-exchange surface area. The step designated secondary septation includes elastogenesis from interstitial fibroblasts. We used microarrays to detail the global prog...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7491 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of murine leukemic T cells from Ikaros-deficient mice and wild type mice to identify critical gene expression events during T-cell leukemogenesis.
The experiment was to compare leukemic T cells from thymic lymphomas from homozygote mice for the IkL/L hypomorphic mutation and non-transformed thymocytes, either of WT or IkL/L genotype. The aim was to identify a gene expression signature specific to the IkL/L tumors.
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-2501 | biostudies-arrayexpress
TranscriptomicsExon array of heart samples of myotonic dystrophic patients
Analysis of alternative splicing of left ventricles heart samples of 3 DM1 adult versus 3 adult controls PolyA RNA from left ventricles (heart) of 3 controls and 3 DM1 patients were analysed on Exon Array (Affymetrix)
ORGANISM(S): Homo sapiens 
2016-01-21 | E-GEOD-67067 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse spontaneous liver tumors of Trim24/TIF1a-null animals
The transcriptional coregulator Trim24 (formerly known as TIF1a) functions in mice as a liver-specific tumor suppressor. Mice carrying a null mutation in the Trim24 gene all develop hepatocellular carcinoma (HCC). We used microarrays to identify the alterations in gene expression patterns associated...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9012 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of murine embryos lacking endogenous retinoic acid signaling
Retinoic acid (RA), an active derivative of the liposoluble vitamin A (retinol), acts as an important signaling molecule during embryonic development, regulating phenomenons as diverse as anterior-posterior axial patterning, forebrain and optic vesicle development, specification of hindbrain rhombom...
ORGANISM(S): Mus musculus 
2013-03-31 | E-GEOD-43578 | biostudies-arrayexpress
TranscriptomicsMolar and incisor development
One of the key questions in developmental biology is how from universally shared molecular mechanisms and pathways, is it possible to generate organs displaying similar or complementary functions, with a wide range of different shapes or tissue organization? The dentition represents a valuable syste...
ORGANISM(S): Mus musculus 
2013-03-31 | E-GEOD-43144 | biostudies-arrayexpress
Sort   by:  
 Page size