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ProteomicsTruncated N-glycans destabilize POMT1 and POMT2 but do not limit cellular O-mannosylation in HEK293 cells
Protein O-mannosylation is initiated by the ER-resident enzymes POMT1 and POMT2, both of which carry multiple N-glycans essential for proper folding and activity. Although congenital disorders of glycosylation type I (CDG-I) disrupt the early N-glycosylation process, their impact on POMT biogenesis ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-02 | PXD073937 | Pride
Alg3  pomt1  pomt2  kiaa1549  n-glycosylation  o-mannosylation 
ProteomicsTruncated N-glycans destabilize POMT1 and POMT2 but do not limit cellular O-mannosylation in HEK293 cells
Protein O-mannosylation is initiated by the ER-resident enzymes POMT1 and POMT2, both of which carry multiple N-glycans essential for proper folding and activity. Although congenital disorders of glycosylation type I (CDG-I) disrupt the early N-glycosylation process, their impact on POMT biogenesis ...
ORGANISM(S): Homo Sapiens 
PXD073179 | panorama
TranscriptomicsExpression data from siliques of wild type and AtHb1-overexpressing plants under moderate hypoxia and standard conditions
Non-symbiotic hemoglobins are ubiquitously expressed proteins known to interact with nitric oxide, an inhibitor of mitochondrial respiration and an important signalling component. We evaluated the underlying molecular mechanisms of AtHb1 (also referred as AtGLB1 or AHb1) function, its effects on str...
ORGANISM(S): Arabidopsis thaliana 
2011-02-15 | E-GEOD-23846 | biostudies-arrayexpress
ProteomicsGlycosyltransferase POMGnT1 deficiency affects N-cadherin-mediated cell-cell adhesion
Deficiencies in the protein O-mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGNT1), a glycosyltransferase involved in the elongation of classic O-mannosyl glycans, are mainly associated with muscle-eye-brain disease (MEB), a genetically heterogeneous congenital muscular dystrophy with brain and ...
ORGANISM(S): Homo sapiens (Human) 
2021-02-18 | PXD021321 | Pride
Pomgnt1 Pmgt1 Protein o-linked-mannose beta-1 2-n-acetylglucosaminyltransferase 1 Meb Pomgnt1 Mannosylation Muscular dystrophy-dystroglycanopathy Muscle-eye-brain disease Pomgnt1 
UnknownFocus-Induced Photoresponse: a novel way to measure distances with photodetectors.
Not available
S-EPMC6003943 | biostudies-literature
UnknownReconstitution and functional characterization of ion channels from nanodiscs in lipid bilayers.
Not available
S-EPMC5881443 | biostudies-literature
UnknownSequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA.
Not available
S-EPMC3789756 | biostudies-literature
UnknownRibose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.
Not available
S-EPMC3182538 | biostudies-literature
ProteomicsTargeted Proteomics Reveals Quantitative Differences in Low Abundance Glycosyltransferases of Patients with Congenital Disorders of Glycosylation
Protein glycosylation is an essential posttranslational modification in all domains of life. Its impairment in human can result in severe diseases named Congenital Disorders of Glycosylation (CDGs). Most of the glycosyltransferases (GTs) responsible for proper glycosylation are polytopic membrane p...
ORGANISM(S): Homo Sapiens 
2024-01-30 | PXD048072 | panorama
MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
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