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MetabolomicsAccumulation of the coumarin scopolin under abiotic stress conditions is mediated by the Arabidopsis thaliana THO/TREX complex
Secondary metabolites are involved in the plant stress response. Among these are scopolin and its active form scopoletin, which are coumarin derivatives associated with reactive oxygen species scavenging and pathogen defence. Here we show that in Arabidopsis thaliana, scopolin accumulation can be in...
2018-02-05 | MTBLS389 | MetaboLights
TranscriptomicsExpression data from Saccharomyces cerevisiae strains deleted for different subunits of the THO/TREX complex
THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis at the interface of transcription-RNA export with a key role in preventing transcription-associated genome instability. We used microarrays to analyze the impact of different THO/TREX mutations on gene expression and found tha...
ORGANISM(S): Saccharomyces cerevisiae 
2011-06-28 | E-GEOD-24802 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding of THO and Sub2 in Saccharomyces cerevisiae
THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis and prevents transcription-associated recombination. Whether or not it has a ubiquitous role in the genome is an open question. ChIP-chip studies reveal that the Hpr1 component of THO and the Sub2 RNA-dependent ATPase have gen...
ORGANISM(S): Saccharomyces cerevisiae 
2011-06-28 | E-GEOD-24960 | biostudies-arrayexpress
TranscriptomicsUsing tiling arrays to precisely detect DNA targets of THO in yeast
Crosslinked DNA from wild type cells or from mutant of the THO complex was analyzed by tiling arrays to precisely detect DNA targets of THO in yeast. DNA coming from SDS-washed DCF pellet and the supernatant SN2k of 2 strains were compared in the study, WT (W303) and mft1 delta (DLY224). The DNA of ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-24 | E-GEOD-32980 | biostudies-arrayexpress
GenomicsRNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
RNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
PRJNA994913 | ENA
GenomicsTranscription and export complex (THO/TREX) coordinates transcription termination in Arabidopsis
Transcription and export complex (THO/TREX) coordinates transcription termination in Arabidopsis
PRJNA529202 | ENA
TranscriptomicsChromatin immunoprecipitation to identify gene-nuclear pore association in wild type and THO mutants of yeast
This work aimed at analysing the genomic loci that are aberrantly docked to the nucleopore in mutants of the THO complex
ORGANISM(S): Saccharomyces cerevisiae 
2008-08-15 | E-TABM-535 | biostudies-arrayexpress
TranscriptomicsExpression profile of ypr045cM-bM-^HM-^F mutant
We report a new protein complex with a role in transcription elongation that is formed by Ypr045c (Thp3) and the Csn12 component of the COP9-signalosome. Thp3-Csn12 is recruited to transcribed genes. Their mutations suppress the gene expression defects of mutants of the THO complex involved in mRNP ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-02-23 | E-GEOD-18994 | biostudies-arrayexpress
TranscriptomicsRNA helicase Ighmbp2 regulates THO complex to ensure cellular mRNA homeostasis
RNA helicases constitute a large protein family implicated in cellular RNA homeostasis and disease development. Here we show that the RNA helicase Ighmbp2, linked to the neuromuscular disorder SMARD1 (DSMA1) associates with polysomes and impacts on translation of cellular mRNAs containing short, GC-...
ORGANISM(S): Homo sapiens 
2024-01-18 | GSE237412 | GEO
UnknownGenes with internal repeats require the THO complex for transcription.
Not available
S-EPMC1599979 | biostudies-literature
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