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GenomicsTHOC2 RNAi microarray in A375 cell line
THOC2 RNAi microarray in A375 cell line
PRJNA431213 | ENA
ProteomicsCompromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment
We implicated the X-chromosome THOC2 gene, which encodes largest subunit of the highly-conserved TREX (Transcription-Export) complex, in a clinically variable neurodevelopmental disorder with intellectual disability as the core phenotype. To study how compromised function of this essential eukaryoti...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-12 | PXD040358 | Pride
Brain Mice Thoc2 Proteomics 
TranscriptomicsTHOC2 RNAi microarray in A375 cell line
Little is known about THOC2 that affect melanoma cell growth,proliferation and invasion siRNAs may be used to address the role of individual gene in these processes. THOC2 RNAi were used to gain a comprehensive overview of all genes involved in cell growth, proliferation, migration and other cellula...
ORGANISM(S): Homo sapiens 
2018-07-01 | GSE109497 | GEO
UnknownKnockdown THOC2 suppresses the proliferation and invasion of melanoma.
Not available
S-EPMC7567448 | biostudies-literature
UnknownA de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia.
Not available
S-EPMC4133931 | biostudies-literature
UnknownExpanding Clinical Presentations Due to Variations in THOC2 mRNA Nuclear Export Factor.
Not available
S-EPMC7026477 | biostudies-literature
UnknownTHOC2 expression and its impact on 5-fluorouracil resistance in glioblastoma multiforme.
Not available
S-EPMC10326588 | biostudies-literature
UnknownTHOC2 Mutations Implicate mRNA-Export Pathway in X-Linked Intellectual Disability.
Not available
S-EPMC4573269 | biostudies-literature
UnknownCompromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment.
Not available
S-EPMC10853216 | biostudies-literature
TranscriptomicsCompromised THOC2, a TREX mRNA export complex scaffold protein, leads to R-loop accumulation, DNA damage and adverse neurodevelopmental outcomes in mice and men
TREX (Transcription-Export) is a highly conserved multi-subunit protein complex that, besides its established role in mRNA export from nucleus to cytoplasm, is involved in transcriptional regulation, stem cell maintenance, 3’ mRNA processing, mitotic progression, and genome stability in eukaryotic c...
ORGANISM(S): Mus musculus 
2023-12-15 | GSE245539 | GEO
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