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ProteomicsMolecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model
LC-MS/MS of Prss37 WT and KO mice male reproductive tract. Title: Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model Authors: Courtney Sutton1,2, Kaori Nozawa1,2, Katarzyna Kent1,2, Alexander Saltzman3, Mei Leng3, Sureshbabu Na...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-07 | MSV000091662 | MassIVE
ProteomicsStress response within the host affects antibiotic persistence and treatment outcome in Staphylococcus aureus infections
Staphylococcus aureus can cause severe invasive infections that require prolonged antibiotic treatment. Although S. aureus can easily acquire antibiotic resistance, even fully susceptible bacteria can persist and survive antibiotic therapy, thus complicating treatment. These so-called persisters are...
ORGANISM(S): Staphylococcus aureus 
2021-09-09 | PXD018372 | Pride
Antibiotic persistence 
TranscriptomicsMetabolic switches and adaptations deduced from the proteomes of Streptomyces coelicolor wild type and phoP mutant grown in batch culture
Bacteria in the genus Streptomyces are soil dwelling oligotrophs and important producers of secondary metabolites. Previously we showed that global mRNA expression was subject to a series of metabolic and regulatory switches during the life time of a fermentor batch culture of S. coelicolor M145. He...
ORGANISM(S): Streptomyces coelicolor 
2011-12-31 | E-GEOD-31068 | biostudies-arrayexpress
TranscriptomicsIntegrative phenotypic and transcriptomic validation of an alveolar-like macrophage model reveals early host–pathogen dynamics during Aspergillus fumigatus infection
The saprophytic mold Aspergillus fumigatus produces small (2-3 µm) airborne spores (conidia) that can reach the lung alveoli upon inhalation. There, they encounter the surfactant-rich environment of the alveolar epithelium and initiate swelling and germination. Primary alveolar macrophages are essen...
ORGANISM(S): Homo sapiens 
2026-10-02 | E-MTAB-17130 | biostudies-arrayexpress
UnknownCRAFT (Cerclage after full dilatation caesarean section): protocol of a mixed methods study investigating the role of previous in-labour caesarean section in preterm birth risk.
Not available
S-EPMC7667480 | biostudies-literature
TranscriptomicsMetabolic modeling of antibiotic and cytotoxic effects of the isoquinoline IQ-238 in S. aureus, S. epidermidis and human cells
Isoquinolines (IQs) are natural substances with antibiotic potential. IQ-238 is a synthetic analog of the novel-type N,C-coupled naphtylisoquinoline (NIQ) alkaloid ancisheynine. Gene expression data, cytotoxicity measurements and metabolic modelling is combined to assess the effects of the N,C-coup...
ORGANISM(S): Staphylococcus aureus 
2015-04-30 | E-GEOD-33832 | biostudies-arrayexpress
UnknownGenomic analysis unveils genome degradation events and gene flux in the emergence and persistence of S. Paratyphi A lineages.
Not available
S-EPMC10171690 | biostudies-literature
UnknownDNA methylation in mice is influenced by genetics as well as sex and life experience.
Not available
S-EPMC6338756 | biostudies-literature
GenomicsBrg1 Modulates Enhancer Activation and Polycomb-mediated Repression in Mesoderm Differentiation [ChIP-exo]
We investigated the genome-wide occupancy changes in normal and Brg1-deleted mesoderm differentiation of mouse embryonic stem cells of chromatin regulators and histone modifications. ChIP exo for BRG1 in 2 conditions: Day4 THF (Control) and Day4 4OHT (Brg1-deleted). 1-2 replicates per condition.
ORGANISM(S): Mus musculus 
2015-03-01 | E-GEOD-63976 | biostudies-arrayexpress
ProteomicsBiofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae
Biofilm formation is generally recognized as a bacterial defense mechanism against environmental threats, including antibiotics, bacteriophages, and leukocytes of the human immune system. Here, we show that for the human pathogen Vibrio cholerae, biofilm formation is not only a protective trait, but...
ORGANISM(S): Homo sapiens (Human) 
2023-05-25 | PXD039579 | Pride
Vibrio cholerae Biofilm formation 
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