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TranscriptomicsC/EBPα induces highly efficient macrophage transdifferentiation of selected B-lymphoma /leukemia cell lines and impairs their tumorigenicity
Earlier work demonstrated that the transcription factor C/EBPα can convert immature and mature murine B lineage cells into functional macrophages. Testing >20 human lymphoma and leukemia B-cell lines, we found that most can be transdifferentiated at least partially into macrophage-like cells, provi...
ORGANISM(S): Homo sapiens 
2013-03-14 | E-GEOD-44700 | biostudies-arrayexpress
TranscriptomicsPostnatal monocyte maturation requires age-dependent initiation of regulatory gene programs when losing birth-associated stress tolerance
We disprove that the impaired Myd88-dependent proinflammatory response of neonatal monocytes is a correlate for immaturity and confirm it as display of transient alarmin-mediated stress tolerization. We find a strong inducibility of TRIF-dependent genes in neonatal monocytes by LPS but a barely dete...
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-78697 | biostudies-arrayexpress
ProteomicsIdentification of regulators of polyploidization presents therapeutic targetsfor treatment of AMKL
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Go...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-01-27 | MSV000078536 | MassIVE
UnknownTransmissible cytotoxicity of multiple myeloma cells by cord blood-derived NK cells is mediated by vesicle trafficking.
Not available
S-EPMC4262774 | biostudies-literature
TranscriptomicsPrimary human CD34+ cells for modeling ETO2-GLIS2 leukemogenesis - Single cell RNAseq
To characterize the consequences of cytokine stimulation, we compared ET02-GLIS2 expressing cells from different origins by single cell transcriptomes (scRNAseq). We analysed FL and CB ET02-GLIS2-expressing CD34+ progeny after 7 days in vitro, human cells from diseased NSG (FL- and FBM-derived) and ...
ORGANISM(S): Homo sapiens 
2024-10-08 | E-MTAB-14140 | biostudies-arrayexpress
UnknownFucosylation with fucosyltransferase VI or fucosyltransferase VII improves cord blood engraftment.
Not available
S-EPMC3883688 | biostudies-literature
TranscriptomicsTranscription profiling of mouse wildtype lungs vs. lung hypomorphic for nmyc
comparison of expression of wildtype lungs and lungs with hypomorphic expression of nmyc. the lungs were pooled from several biological samples. The hypomorphoic mutant was orignally published in Moens CB et al [PMID: 1577267]. this is part of a larger collection of data comparing nmyc misexpression...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6079 | biostudies-arrayexpress
TranscriptomicsGas7 male transgenic liver expression vs FVB male wildtype control
A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our m...
ORGANISM(S): Mus musculus 
2009-03-07 | E-GEOD-11996 | biostudies-arrayexpress
UnknownAllosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold.
Not available
S-EPMC4868099 | biostudies-literature
UnknownIn vitro evolution of ciprofloxacin resistance in Neisseria commensals and derived mutation population dynamics in natural Neisseria populations.
Not available
S-EPMC11774118 | biostudies-literature
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