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TranscriptomicsHDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation
Increasing evidence has demonstrated that epigenetic factors can profoundly influence gene expression and, in turn, influence resistance or susceptibility to disease. Epigenetic drugs, such as histone deacetylase (HDAC) inhibitors, are finding their way into clinical practice, although their exact m...
ORGANISM(S): Homo sapiens 
2015-04-10 | E-GEOD-67733 | biostudies-arrayexpress
UnknownAccelerated methotrexate, vinblastine, doxorubicin, and cisplatin is safe, effective, and efficient neoadjuvant treatment for muscle-invasive bladder cancer: results of a multicenter phase II study with molecular correlates of response and toxicity.
Not available
S-EPMC4050203 | biostudies-literature
TranscriptomicsCwc23, an essential J-protein critical for pre-mRNA splicing with a dispensable J-domain
J-proteins are structurally diverse, obligatory co-chaperones of Hsp70s, each with a highly conserved J-domain that plays a critical role in stimulation of Hsp70’s ATPase activity. The essential protein, Cwc23, is one of 13 J-proteins found in the cytosol and/or nucleus of Saccharomyces cerevisiae...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-21 | E-GEOD-18485 | biostudies-arrayexpress
TranscriptomicsA Short-Term Study Investigating the Estrogenic Potency of Diethylstilbesterol in the Fathead Minnow (Pimephales promelas): Recovery phase
Diethylstilbestrol (DES) is a synthetic estrogen that has been banned for use in humans, but still is employed in livestock and aquaculture operations in some parts of the world. Detectable concentrations of DES in effluent and surface waters have been reported to range from slightly below 1 to gre...
ORGANISM(S): Pimephales promelas 
2012-09-20 | E-GEOD-36466 | biostudies-arrayexpress
TranscriptomicsA Short-Term Study Investigating the Estrogenic Potency of Diethylstilbesterol in the Fathead Minnow (Pimephales promelas): Exposure Phase
Diethylstilbestrol (DES) is a synthetic estrogen that has been banned for use in humans, but still is employed in livestock and aquaculture operations in some parts of the world. Detectable concentrations of DES in effluent and surface waters have been reported to range from slightly below 1 to gre...
ORGANISM(S): Pimephales promelas 
2012-09-20 | E-GEOD-36465 | biostudies-arrayexpress
OtherSirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.
Data from ProteomeXchange, PXD ID: PXD001447. Experiment: SIRT4_MITO_MOCK1, file: SIRT4_MITO_MOCK1_05.mzml. Published as part of Cell. 2014 Dec 18;159(7):1615-25 . From the Abstract: {{i}} ... Here, we establish SIRT4 as a cellular lipoamidase that regulates the pyruvate dehydrogenase complex (PDH)...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320006423 | GPMDB
Resource Reanalysis 
UnknownDefinitive chemoradiotherapy versus neoadjuvant chemoradiotherapy followed by radical surgery for locally advanced oesophageal squamous cell carcinoma: meta-analysis.
Not available
S-EPMC9728519 | biostudies-literature
UnknownThree-Year Outcomes With Hypofractionated Versus Conventionally Fractionated Whole-Breast Irradiation: Results of a Randomized, Noninferiority Clinical Trial.
Not available
S-EPMC6286164 | biostudies-literature
TranscriptomicsGene Expression Profiles in BA46 of Subjects with Schizophrenia and Matched Controls
Results from clinical and imaging studies provide evidence for changes in schizophrenia with disease progression, however, the underlying molecular differences that may occur at different stages of illness have not been investigated. To test the hypothesis that the molecular basis for schizophrenia...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-21138 | biostudies-arrayexpress
UnknownOutcome and Prognostic Factors in Stage III Favorable-Histology Wilms Tumor: A Report From the Children's Oncology Group Study AREN0532.
Not available
S-EPMC5773840 | biostudies-literature
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