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TranscriptomicsType-I interferon inducible genes 26 weeks after mCMV infection in Siglec-H wt and Siglec-H ko mice and their non infected controls
Type I interferons are critical anti-viral cytokines during virus infections and have also been implicated in the pathogenesis of systemic lupus erythematosus (SLE). The secretion of type I interferon of pDCs is modulated by Siglec-H, a DAP12 associated receptor on pDCs. We showed that Siglec-H defi...
ORGANISM(S): Mus musculus 
2016-03-16 | E-GEOD-79248 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat insulinoma line INS-1 to identify targets of HNF1b mutants in INS-1
A rat insulinoma cell line (INS-1) was generated that contains a FRT site for FLP recombinase mediated site specific integration of specific genes. In addition, the line contains the tetracycline repressor allowing tetracycline (tet) induction of the introduced gene. By comparing the gene expression...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1590 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Drosophila neural stem cells reveals a transcriptional network for self-renewal.
Drosophila neuroblasts have emerged as a model for stem cell biology that is ideal for genetic analysis but is limited by the lack of cell-type specific gene expression data. Here, we describe a methodology to isolate large numbers of pure neuroblasts and differentiating neurons that retain both cel...
ORGANISM(S): Drosophila melanogaster 
2012-08-21 | E-GEOD-38764 | biostudies-arrayexpress
TranscriptomicsExpression data from human CD4 or CD8 T-cells isolated from PBMC cultured at a low cell density (LDC) or high cell density (HDC)
Research in human immunobiology is mainly based on working with peripheral blood mononuclear cells (PBMC). However, recent investigations have shown that circulating CD4+ T cells are less sensitive to several T-cell activating monoclonal antibodies (mAb) and to recall antigens as compared to tissue-...
ORGANISM(S): Homo sapiens 
2015-06-09 | E-GEOD-51288 | biostudies-arrayexpress
TranscriptomicsMode of action studies of the novel bisquaternary bisnaphthalimide MT02 against Staphylococcus aureus
Screening of various bisquaternary bisnaphthalimides against a variety of human pathogens revealed one compound, designated MT02, with strong inhibitory effects against gram-positive bacteria. The minimal inhibitory concentrations ranged from 0.31 µg/ml against community-acquired methicillin resista...
ORGANISM(S): Staphylococcus aureus 
2011-01-04 | E-GEOD-23077 | biostudies-arrayexpress
TranscriptomicsComparison between Saccharomyces cerevisiae HS 10, HS 34 and HS 12, HS 37
Gene expression of different flocculent (HS 10 and HS 34) and powdery (HS 12 and HS 37) yeast strains compared to each other during exponential and stationary growth phase was analysed. The isolation of RNA was done by disruption of the cells under liquid nitrogen using mortar and pistil and then th...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-11 | E-GEOD-12369 | biostudies-arrayexpress
TranscriptomicsDistinct classes of genes behave as either drivers or dependents of replication timing switches (Replication-Timing).
Duplication of the genome in mammalian cells occurs in a defined temporal order referred as its replication-timing program (RT). RT is regulated in units of 400-800 Kb referred as replication domains (RDs) and changes dynamically during development. Changes in RT are generally coordinated with trans...
ORGANISM(S): Homo sapiens 
2015-05-28 | E-GEOD-63428 | biostudies-arrayexpress
ProteomicsAnalysis of the MAGED2 interactome
The MAGED2 interactome was analyzed in HEK293T cells using three different strategies.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080703 | MassIVE
UnknownPerformance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia.
Not available
S-EPMC9877422 | biostudies-literature
GenomicsOCAC OncoArray data
Germline genotype data on 56,479 ovarian cancer cases and controls
EGAD00010001192 | EGA
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