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MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
MetabolomicsBacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show that the enzyme cystathionine γ-lyase (CTH) is induced in macrophages infected with pathogenic ba...

2020-05-15 | MTBLS696 | MetaboLights
Proteomics,MultiomicsLIQUID publication data - human plasma lipids
These files are associated with the publication of the LIQUID identification tool for lipid MS/MS spectra.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-11-28 | MSV000080359 | MassIVE
TranscriptomicsMDA-MB-231 eIF4E RIP-CHIP
Cytoplasmic RNA bound to eIF4E was pulled down from MDA-MB-231 cells to determine the influence of radiation on eIF4E mRNA binding 4 samples were analyzed with 3 biological replicates
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-36179 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse spinal chord from a mouse model of severe spinal muscular atrophy
Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy
ORGANISM(S): Mus musculus 
2009-12-07 | E-MEXP-2428 | biostudies-arrayexpress
TranscriptomicsDiverse phospho-signaling networks mediate RTK dependent growth and survival in childhood ALL [gene expression]
Deregulated RTK activity has been implicated as a causal leukemogenic factor in the context of molecular aberrations that perturb differentiation in the hematopoietic lineage such as in childhood ALL. A deeper understanding of RTK signaling processes on a system-wide scale will be key in defining cr...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-42001 | biostudies-arrayexpress
TranscriptomicsDiverse phospho-signaling networks mediate RTK dependent growth and survival in childhood ALL [copy number]
Deregulated RTK activity has been implicated as a causal leukemogenic factor in the context of molecular aberrations that perturb differentiation in the hematopoietic lineage such as in childhood ALL. A deeper understanding of RTK signaling processes on a system-wide scale will be key in defining cr...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-42054 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of human normal somatic tissues, placenta, sperm and an immortalized cell line to identify tissue-specific differentially methylated regions
Genome-wide DNA methylation reference profiles of 13 normal somatic tissues, placenta, sperm and an immortalized cell line using the meDIP technique and a custom oligonucleotide array targetting the vast majority of annotated TSSs and non-promoter CGIs in the human genome.
ORGANISM(S): Homo sapiens 
2008-04-30 | E-TABM-445 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat eye eQTL experiment
We used expression quantitative trait locus mapping in the laboratory rat (Rattus norvegicus) to gain a broad perspective of gene regulation in the mammalian eye and to identify genetic variation relevant to human eye disease. Of >31,000 gene probes represented on an Affymetrix expression microarray...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5680 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse nmyc misexpression in lung (gain of function)
Understanding how lung progenitor cells balance; proliferation against differentiation is relevant to clinical; disorders such as bronchopulmonary dysplasia of; premature babies and lung cancer. Previous studies have; established that lung development is severely disrupted in; mouse mutants with red...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6077 | biostudies-arrayexpress
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