Thomas Niklas N

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Metabolomics (3)
Transcriptomics (2)

Organisms

Homo sapiens (2)

Repository

MetaboLights (3)
biostudies-arrayexpress (2)

Technology Type

Mass spectrometry (2)
Mass spectrometry assay (1)

Instrument Platform

6530 Q-TOF LC/MS (Agilent) (2)
NextSeq 550 (1)
Liquid Chromatography MS - negative - hilic (1)
Liquid Chromatography MS - negative - reverse phase (1)
Liquid Chromatography MS - positive - hilic (1)
Liquid Chromatography MS - positive - reverse phase (1)

Publication Date

2026 (2)
2013 (1)
2021 (1)
2018 (1)

CHEBI ID

CHEBI:139282 (2)
CHEBI:2106 (2)
CHEBI:86632 (2)
CHEBI:86635 (2)
CHEBI:9300 (2)
CHEBI:139241 (1)
CHEBI:139281 (1)
CHEBI:139293 (1)
CHEBI:139294 (1)
CHEBI:139295 (1)
CHEBI:139297 (1)
CHEBI:139298 (1)
CHEBI:139313 (1)
CHEBI:149477 (1)
CHEBI:149478 (1)
CHEBI:149479 (1)
CHEBI:16428 (1)
CHEBI:18370 (1)
CHEBI:2268 (1)
CHEBI:26658 (1)
CHEBI:32304 (1)
CHEBI:48299 (1)
CHEBI:67119 (1)
CHEBI:86542 (1)
CHEBI:86593 (1)
CHEBI:86637 (1)
CHEBI:86944 (1)

Metabolite Name

5-O-Caffeoylshikimic acid (2)
G(8–O–4)S(8–8)S (2)
G(8–O–4)S(8–O–4)S(8–5)G (2)
G(e8–O–4)S(8–5)G (2)
Suberic acid (2)
(4xi)-2-O-(4-Hydroxybenzoyl)-6-O-(3,4,5-trihydroxybenzoyl)-D-ribo-hexopyranose (1)
2-(3-benzoylphenyl)-3,5,7-trihydroxychromen-4-one (1)
2-cis,4-trans-xanthoxin (1)
4-coumaroylshikimate (1)
7-Hydroxyflavone (1)
7-deoxyloganin (1)
Acidic sesquiterpenoid (1)
Coenzyme Q4 (1)
DGDG(36:5) (1)
Feruloyl glycerol (1)
G(8-O-4)S(8-8)S(8-O-4)G (1)
G(8–O–4)S(8–O–4)S(8–8)S (1)
G(8–O–4)SP(8–8)S (1)
G(e8–O–4)S(8–5)G' (1)
G(t8-O-4)S(8-8)G (1)
G(unknown)-G(t8–O–4)G(8–5)G′ (1)
HCH-sinapic acid (1)
Hydroxycaproic acid (1)
Iso-erythritol (1)
MGDG(36:5) (1)
MGDG(36:6) (1)
SP(8-8)S (1)
Salirepin (1)
UDP-alpha-D-galactose (1)

Study type

Transcription profiling by array (1)
RNA-seq of coding RNA (1)

Release Date

2026 (1)
2013 (1)

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Overexpression of vesicle-associated membrane protein PttVAP27-17 as a tool to improve biomass production and the overall saccharification yields in Populus trees

Background

Bioconversion of wood into bioproducts and biofuels is hindered by the recalcitrance of woody raw material to bioprocesses such as enzymatic saccharification. Targeted modification of the chemical composition of the feedstock can improve saccharification but this gain is often abr...

2021-10-06 | MTBLS628 | MetaboLights

A multi-omics approach reveals functions of Secretory Carrier-Associated Membrane Proteins in wood formation of Populus trees

Secretory Carrier-Associated Membrane Proteins (SCAMPs) are highly conserved proteins that are involved in membrane trafficking. An integrated approach was taken to elucidate function of SCAMPs in wood formation of Populus trees. The metabolomics analyses were performed in woody tissues of transgeni...

2018-01-08 | MTBLS478 | MetaboLights

Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs

Activating PIK3CA mutations, present in up to 40% of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (Her2-) breast cancer (BC) patients, can be effectively targeted with the alpha isoform-specific PI3K inhibitor Alpelisib. This treatment significantly improves ...

2026-08-21 | MTBLS11671 | MetaboLights

PRRX1 transcription factor association to type 2 diabetes

Primary human adipose stromal cells (hASCs) from rs4684847 CC risk allele carriers were cultured and induced to differentiate into adipocytes, and simultaneously transfected for 72h with non-targeting siRNA or siRNA targeting PRRX1 (n=10) or both PRRX1 and PPARG (subset of the subjects, n=4).

ORGANISM(S): Homo sapiens

2013-12-01 | E-MTAB-1906 | biostudies-arrayexpress

HTG EdgeSeq analysis of parental and CDK4/6i-resistant (Ribociclib or Palbociclib) T47D breast cancer cell clones

Do illuminate the vulnerabilities of CDK4/6i-resistant T47D breast cancer cells, we created CDK4/6i-resistant T47D cell clones through a gradual dose escalation protocol using the selective CDK4/6 inhibitors Ribociclib and Palbociclib. We then performed gene expression analysis targeting 2549 genes ...