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MetabolomicsATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth

Lipid droplet (LD) growth mechanisms and the roles of LD-associated lipid transfer proteins remain poorly understood. Here, we show that the autophagy lipid transfer protein ATG2A has an anabolic role and promotes LD expansion by transferring diacylglycerol (DAG), and potentially triacylglycerol ...

2025-09-07 | MTBLS12951 | MetaboLights
MetabolomicsA Pilot Characterization of the Human Chronobiome
Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using forced desynchrony increases cardiovascular risk factors in humans. Here we integrated data ...
2018-05-16 | MTBLS656 | MetaboLights
TranscriptomicsChromatin Immunoprecipitation Analysis of Aryl Hydrocarbon Receptor Binding in a Mouse B-cell Line (CH12.LX) Activated with Lipopolysaccharide and Treated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin
The aryl hydrocarbon receptor (AHR) agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters differentiation of B cells and suppresses antibody production. The objectives of this study was to use a combination of whole genome, microarray-based chromatin immunoprecipitation (ChIP-on-chip) and time ...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23708 | biostudies-arrayexpress
UnknownImpact of Vascular Geometry on Thrombosis in Pediatric Patients With Modified Blalock-Taussig-Thomas Shunt: A Pilot Study.
Not available
S-EPMC12132624 | biostudies-literature
MetabolomicsMetabolic Response of a Chemolithoautotrophic Archaeon to Carbon Limitation

The ubiquitously distributed ammonia-oxidizing archaea generate energy from ammonia and build cell mass from inorganic carbon sources, thereby contributing to both the global nitrogen and carbon cycles. However, little is known about the regulation of their predicted core carbon metabolism. A the...

2025-09-27 | MTBLS11689 | MetaboLights
UnknownSex Differences in rt-PA Utilization at Hospitals Treating Stroke: The National Inpatient Sample.
Not available
S-EPMC5623663 | biostudies-literature
UnknownHeavy metals in spices from Lancaster, PA: arsenic, cadmium, and lead exposure risks and the need for regulation.
Not available
S-EPMC12037643 | biostudies-literature
TranscriptomicsDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neu...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-42424 | biostudies-arrayexpress
TranscriptomicsHIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs
Over the last decade, small noncoding RNA molecules such as microRNAs (miRNAs) have emerged as critical regulators in the expression and function of eukaryotic genomes. It has been suggested that viral infections and neurological disease outcome may also be shaped by the influence of small RNAs. Thi...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-42423 | biostudies-arrayexpress
UnknownA step towards personalizing next line therapy for resected pancreatic and related cancer patients: A single institution's experience.
Not available
S-EPMC7498307 | biostudies-literature
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