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ProteomicsCoupling microdroplet-based sample preparation, multiplexed isobaric labeling, and nanoflow peptide fractionation for deep proteome profiling of tissue microenvironment
Existing spatially-resolved proteomics technologies cannot provide deep proteome coverage due to limited sensitivity and poor sample recovery. Herein, we seamlessly combined laser capture microdissection with a low-volume sample processing technology that includes a microfluidic device named microPO...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-25 | MSV000093925 | MassIVE
TranscriptomicsTissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial
The objectives of this study were to measure effects of an aspirin intervention on gene expression in normal colonic epithelial and stromal tissue in healthy humans and to determine whether response differed by UGT1A6*2 genotype. We also sought to characterize gene expression differences within colo...
ORGANISM(S): Homo sapiens 
2015-07-30 | E-GEOD-71571 | biostudies-arrayexpress
ProteomicsCatechol-O-Methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis and protein folding in schizophrenia
Dysregulation of dopamine (DA) signaling and redox homeostasis contributes to multiple neuropsychiatric and neurodegenerative disorders. Polymorphisms that influence the activity of catechol‑O‑methyltransferase (COMT), an enzyme critical for degrading dopamine (DA) in the dorsolateral prefrontal cor...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-28 | PXD075030 | Pride
Limited proteolysis Thermo-fisher ascend Rat Pc12 cells 
UnknownHydrogen/Deuterium Exchange for Chiral Stability Assessment in Acidic Methine-Containing Compounds.
Not available
S-EPMC12676523 | biostudies-literature
UnknownTargeting the succinate receptor effectively inhibits periodontitis.
Not available
S-EPMC9533417 | biostudies-literature
UnknownEvaluation of the antitumor activity of dacomitinib in models of human bladder cancer.
Not available
S-EPMC3883970 | biostudies-literature
ProteomicsResidual tissue repositories as a resource for population-based cancer proteomic studies
Background Mass spectrometry-based proteomics has become a powerful tool for the identification and quantification of proteins from a wide variety of biological specimens. To date, the majority of studies utilizing tissue samples have been carried out on prospectively collected fresh frozen or optim...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-08 | MSV000088548 | MassIVE
ProteomicsUnique Histone Proteoforms by Differential Top Down MS
H3.1 and H3.3 quadrupole isolated and fragmented by ETD and EThcD on an Orbitrap Fusion Lumos. Comparison of two cell lines.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-07-14 | MSV000079191 | MassIVE
TranscriptomicsProfiling of spatio-temporally regulated transcripts during cerebral corticogenesis in the mouse
The cerebral cortex plays an important role in cognitive function and specialized perception in mammals and its development requires highly specific spatio-temporal control of gene expression. The study identified stage- and region-specific markers throughout cerebral corticogenesis at various impor...
ORGANISM(S): Mus musculus 
2009-09-25 | E-GEOD-15031 | biostudies-arrayexpress
UnknownGeographic and temporal trends in antimicrobial nonsusceptibility in Streptococcus pneumoniae in the post-vaccine era in the United States.
Not available
S-EPMC3778966 | biostudies-literature
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