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ProteomicsPharmacokinetic analysis of a novel human EGFRvIII:CD3 bispecific antibody in plasma and whole blood using a high-resolution targeted mass spectroscopy approach
Bi-specific single change antibody fragments (bi-scFv) represent an emerging class of biotherapeutics. We recently developed a fully human bi-scFv (EGFRvIII:CD3 bi-scFv) with the goal of redirecting CD3-expressiong T cells to recognize and destroy malignant, EGFR-expressing glioma. In mice, we showe...
ORGANISM(S): Homo Sapiens Mus Musculus 
2019-07-09 | PXD012472 | panorama
UnknownRobustness of performance during domain change in an esport: A study of within-expertise transfer.
Not available
S-EPMC10703280 | biostudies-literature
ProteomicsOn-board Preconcentration Microchip Capillary Electrophoresis Based TMT-PRM-LIVE for High-throughput Selectivity Profiling of Deubiquitinase Inhibitors
On-board Preconcentration Microchip Capillary Electrophoresis Based TMT-PRM-LIVE for High-throughput Selectivity Profiling of Deubiquitinase Inhibitors
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-24 | MSV000089122 | MassIVE
ProteomicsScanning quadrupole DIA - Scanning Quadrupole Data Independent Acquisition - Part A
A scanning quadrupole data independent acquisition (DIA) method is described and characterised for the qualitative and quantitative label free proteomic analysis of complex biological samples. The principle of the scanning quadrupole DIA is discussed and the effect of the optimization of analytical ...
ORGANISM(S): Homo sapiens (Human) 
2017-09-14 | PXD005869 | Pride
Dia 
ProteomicsABRF PRG 2012: Longitudinal QC in Routine Peptide LC-MS/MS Analyses
Questions concerning data quality and reproducibility of proteomic laboratories spurred the ABRF-PRG group to design a study to systematically assess the reproducibility of proteomic laboratories. Sixty four participants were recruited from the broader mass spectrometry community and were asked to ...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2015-04-28 | MSV000079117 | MassIVE
UnknownMetaprotein expression modeling for label-free quantitative proteomics.
Not available
S-EPMC3436780 | biostudies-literature
UnknownIdentifying challenges to implementation of clinical practice guidelines for sentinel lymph node biopsy in patients with melanoma in Australia: protocol paper for a mixed methods study.
Not available
S-EPMC7050375 | biostudies-literature
ProteomicsComprehensive respiratory phenomics across multiple models of mitochondrial protein hyperacylation reveals a paradoxically marginal impact on bioenergetics
Acyl CoA metabolites derived from catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of post-translation modifications (PTMs). Mass spectrometry-based detection of thousands of acyl-PTMs scattered throughout the proteome has established...
ORGANISM(S): Mus Musculus (mouse) 
2019-02-07 | PXD011375 | JPOST Repository
UnknownS-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes.
Not available
S-EPMC4649751 | biostudies-literature
UnknownSources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories.
Not available
S-EPMC2453529 | biostudies-literature
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