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TranscriptomicsGene expression data from HD mutant and wild type ST14A cells, differentiated for 24 hours and treated with vehicle (DMSO) or with 5M-BM-5M MIND4
Activation of cellular responses through the NRF2/KEAP1/ARE pathway is a promising therapeutic strategy to counter neurodegeneration. The present study identified a novel lead compound, MIND4, which induces canonical NRF2-dependent responses and is protective in primary neurons, neuronal slice cultu...
ORGANISM(S): Rattus norvegicus 
2013-08-01 | E-GEOD-49392 | biostudies-arrayexpress
TranscriptomicsGene expression data from MGHU3 bladder cancer cells (FGFR3-Y375C) treated with TAK1 siRNA and/or PD173074
The NFM-NM-:B transcription factor is constitutively active in a number of hematologic and solid tumors, and many signaling pathways implicated in cancer are likely connected to NFM-NM-:B activation. A critical mediator of NFM-NM-:B activity is TGFM-NM-2-activated kinase 1 (TAK1). Here, we identif...
ORGANISM(S): Homo sapiens 
2013-11-19 | E-GEOD-52452 | biostudies-arrayexpress
TranscriptomicsExpression data from human induced pluripotent stem cell derived NSCs and striatal-like cells
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded stretch of CAG trinucleotide repeats that results in neuronal dysfunction and death. We made induced pluripotent stem cell (iPSC) lines from HD patients and controls. Though no obvious effects of the CAG expan...
ORGANISM(S): Homo sapiens 
2012-04-24 | E-GEOD-37517 | biostudies-arrayexpress
TranscriptomicsTargeting H3K4 methylation as a therapeutic strategy for Huntington's disease (RNA-seq)
Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3...
ORGANISM(S): Mus musculus 
2013-07-18 | E-GEOD-48962 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat FGFR3-K650E mutant and wild type PC12 cells
To investigate signaling pathways activated by FGFR3 mutations through an analysis of altered expression of downstream transcriptional targets, we performed gene expression profiling of stably transfected inducible PC12 cells expressing a chimeric receptor (PFR3) consisting of the extracellular doma...
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2606 | biostudies-arrayexpress
GenomicsTargeting H3K4 methylation as a therapeutic strategy for Huntington's disease (ChIP-seq)
Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3...
ORGANISM(S): Mus musculus 
2013-07-18 | E-GEOD-48960 | biostudies-arrayexpress
UnknownIntegrating genomics into Canadian oncology nursing policy: Insights from a comparative policy analysis.
Not available
S-EPMC11415546 | biostudies-literature
UnknownLack of Evidence to Guide Deprescribing of Antihyperglycemics: A Systematic Review.
Not available
S-EPMC5306119 | biostudies-literature
TranscriptomicsTranscription profiling of rat Htt14A2.5 (PC12) cells expressing truncated Htt exon 1-EGFP fusion protein
Htt14A2.5 is a clonal rat pheochromocytoma (PC12) cell line, that expresses a truncated form of expanded repeat Htt exon 1 protein fused at the C-terminus to enhanced green fluorescent protein (EGFP). For total RNA preparation, ~3 x 105 cells were plated on 150 mm plates and the following day eithe...
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2602 | biostudies-arrayexpress
UnknownIn vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA.
Not available
S-EPMC4311832 | biostudies-literature
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