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TranscriptomicsDEN-induced HCC in c-Met knockout mice
HGF has been reported to have both positive and negative effects on carcinogenesis. Here we show that the loss of c-Met signaling in hepatocytes enhanced rather than suppressed the early stages of chemical hepatocarcinogenesis. c-Met conditional knockout mice (c-metfl/fl, AlbCre+/-; MetLivKO) treate...
ORGANISM(S): Mus musculus 
2008-08-09 | E-GEOD-8747 | biostudies-arrayexpress
TranscriptomicsProfiling of hepatic progenitor cells isolated from Egfr fl/fl and Met fl/fl murine control livers
Transcriptomic profiling; Determination of the transcriptomic similarity between Egfr fl/fl and Met fl/fl progenitor cells isolated from excised livers (n=3, each) Profiling of hepatic progenitor cells
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-46981 | biostudies-arrayexpress
TranscriptomicsDifferentiation stage-specific donor memory in induced pluripotent stem cells (iPSC) generated from hepatic lineage cells
Recent studies suggested that embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) may represent different pluripotent states as defined by gene expression profiles and differentiation potential. Here we addressed a contribution of a lineage stage-specific donor cell memory in mod...
ORGANISM(S): Mus musculus 
2012-10-02 | E-GEOD-33110 | biostudies-arrayexpress
TranscriptomicsHuman Hepatocellular Carcinoma study
Global gene expression patterns of 91 human hepatocellular carcinomas (HCC) were analyzed to define the molecular characteristics of the tumors and to test the prognostic value of the expression profiles. Total RNAs were isolated from frozen liver tissue using CsCl density gradient centrifugation me...
ORGANISM(S): Homo sapiens 
2004-10-28 | E-GEOD-1898 | biostudies-arrayexpress
TranscriptomicsTGFbeta signalling in fibroblasts.
Murine embryonic fibroblasts, wild type or Alk5 knock outs, stimulated and unstimulated with TGFbeta.
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-1742 | biostudies-arrayexpress
TranscriptomicsmTOR inhibitors synergistically induce regression, reversal of gene expression and autophagy in hepatocellular carcinoma
The mTOR-allosteric inhibitor, RAD001, in combination with a PI3K/mTOR ATP-site competitive inhibitor, BEZ235, causes gene reprogramming, autophagy and tumor regression, in a mouse model approximating human HCC with poor prognosis, leading to an investigator Phase 1B-2 clinical trial. Comparative st...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-37129 | biostudies-arrayexpress
TranscriptomicsIdentification of cholangiocarcinoma-like gene expression traits in hepatocellular carcinoma
We performed gene expression profiling of hepatocellular carcinoma (HCC), cholangiocarcinoma (CC), and mixed type of combined HCC and CC (CHC). In comparison of the profiles, a novel class of HCC expressing CC-like traits was identified. Gene expression profiling of 70 hepatocellular carcinoma (HCC)...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-15765 | biostudies-arrayexpress
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