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ProteomicsThe Serine/Threonine kinase PrkC of Clostridioides difficile regulates export of CD1135, a septal peptidoglycan hydrolase
Cell growth and division require a balance between synthesis and hydrolysis of the peptidoglycan (PG). Inhibition of PG synthesis or uncontrolled PG hydrolysis can be lethal for the cells, making it imperative to control peptidoglycan hydrolase (PGH) activity. The activity of several enzymes involv...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2021-04-08 | PXD021541 | Pride
Phosphoproteomics Clostridium difficile Qexactive plus Phostag 
ProteomicsPhosphatase POPX2 exhibits dual regulatory functions in cancer metastasis
Cancer metastasis is a complex mechanism involving multiple processes. In an earlier study, we reported that the levels of serine/threonine phosphatase POPX2were positively correlated with cancer cell motility through modulating MAPK signaling. Surprisingly, here we found that POPX2 knockdown cells ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080801 | MassIVE
ProteomicsQuantitative chemical proteomic profiling of phosphoprotein phosphatases
We have developed a chemical proteomic strategy for the systematic interrogation of endogenous phosphoprotein phosphatases (PPP) and their interacting proteins, including regulatory and scaffolding subunits, and substrates (the 'PPPome'). PPPs are captured using an immobilized non-selective PPP inhi...
ORGANISM(S): Neurospora Crassa (ncbitaxon:5141) Candida Albicans (ncbitaxon:5476) Saccharomyces Cerevisiae (ncbitaxon:4932) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) Schizosaccharomyces Pombe (ncbitaxon:4896) 
2017-07-07 | MSV000081226 | MassIVE
GenomicsThreonine-4 of Mammalian RNA Polymerase II CTD is Targeted by Polo-like Kinase-3 and Required for Transcriptional Elongation
Eukaryotic RNA polymerase II (Pol II) has evolved an array of heptad repeats with the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 at the carboxy-terminal domain (CTD) of the large subunit (Rpb1). Differential phosphorylation of Ser2, Ser5, and Ser7 in the 5M-bM-^@M-^Y and 3M-bM-^@M-^Y regi...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-37519 | biostudies-arrayexpress
TranscriptomicsStp1 and Stk1 regulated genes during S. aureus post-exponential phase growth
Genes that showed altered expression in Stk1 and Stp1 deficient Staphylococcus aureus Newman were identified. strain comparison, global regulation Deletion mutants were examined for alterations in gene expression.
ORGANISM(S): Staphylococcus aureus 
2010-04-22 | E-GEOD-21426 | biostudies-arrayexpress
UnknownRegulation of homocysteine metabolism by Mycobacterium tuberculosis S-adenosylhomocysteine hydrolase.
Not available
S-EPMC3719076 | biostudies-literature
OtherAnalysis of the Candida albicans phosphoproteome.
Data from ProteomeXchange, PXD ID: PXD001844. File: qe+00163.mzml. Published as part of Eukaryot Cell. 2015 Mar 6. pii: EC.00011-15 . From the Abstract: {{i}} ... Here, we contribute to our understanding of phosphorylation in C. albicans regulation, we performed a deep analysis of the phosphoproteo...
ORGANISM(S): Candida_albicans_refseq 
GPM32320014317 | GPMDB
Resource Reanalysis 
UnknownThe phosphatase activity of soluble epoxide hydrolase regulates ATP-binding cassette transporter-A1-dependent cholesterol efflux.
Not available
S-EPMC6787517 | biostudies-literature
ProteomicsCouzens_Hippo_interactome_set3_P86_VS5_VS6_June22_2013
Interaction proteomics; FLAG AP-MS. Supplementary files for the Hippo Interactome manuscript by Couzens et al. This dataset consists of 20 files (specificity of MOB1 vs MOB4 and okadaic acid time course). See "README" file and sample description in the "Methods and Protocols" folder.
2013-06-22 | MSV000078446 | MassIVE
UnknownBacillus anthracis chain length, a virulence determinant, is regulated by membrane localized serine/threonine protein kinase PrkC.
Not available
S-EPMC8117516 | biostudies-literature
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