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MetabolomicsInvestigation of the threonine metabolism of Echinococcus multilocularis: EmTDH as a potential drug target in alveolar echinococcosis
Alveolar echinococcosis is a severe zoonotic disease caused by the fox tapeworm E. multilocularis. New treatment options are urgently needed. Whole-organism-based screening allows the discovery of potential new anti-echinococcal compounds, but suffers from low- to medium-throughput. An alternative a...
2026-09-14 | MTBLS10738 | MetaboLights
MetabolomicsMetabolome and proteome changes in skeletal muscle and blood of pre-weaning calves fed leucine and threonine supplemented diets

In pre-weaning calves, both leucine and threonine play important roles in growth and muscle metabolism. In this study, metabolomics, proteomics and clinical chemistry were used to assess the effects of leucine and threonine supplementation added to milk replacer on 14 newborn Holstein male calves...

2020-02-20 | MTBLS1045 | MetaboLights
MetabolomicsElevated CO2 and virus infection impacts wheat and aphid metabolism

INTRODUCTION: The aphid Rhopalosiphum padi L. is a vector of Barley yellow dwarf virus (BYDV) in wheat and other economically important cereal crops. Increased atmospheric CO2 has been shown to alter plant growth and metabolism, enhancing BYDV disease in wheat. However, the bioch...

2019-01-16 | MTBLS622 | MetaboLights
MetabolomicsSerine Metabolism Tunes Immune Responses To Promote Oreochromis niloticus Survival upon Edwardsiella tarda Infection
Overactive immune response is a critical factor triggering host death upon bacterial infection. However, the mechanism behind the regulation of excessive immune responses is still largely unknown, and the corresponding control and preventive measures are also to be explored. In this study, we find t...
2021-08-18 | MTBLS2974 | MetaboLights
ProteomicsThreonine concentration effect on L. lactis growth
L. lactis was grown in steady-state cultures at specific growth rate 0.2 h-1. The concentration of L-threonine in the growth environment was smoothly increased from 1.24mM to 4mM and proteome measurements were carried out to detect proteins involved in threonine metabolism.
ORGANISM(S): Lactococcus lactis 
2015-03-19 | PXD001602 | Pride
Lactococcus lactis Silac Threonine metabolism 
TranscriptomicsCodY in Staphylococcus aureus: regulatory link between metabolism and virulence gene expression
CodY is a conserved regulator in gram-positive organisms described to repress metabolic genes mainly involved in nitrogen metabolism but also to control the expression of virulence genes in pathogens. We constructed codY gene-replacement mutants in three unrelated S. aureus strains (Newman, UAMS-1, ...
ORGANISM(S): Staphylococcus aureus subsp. aureus USA300 
2008-11-06 | E-GEOD-12340 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of the eukaryotic-type ser/thr kinase PknB in Staphylococcus aureus
The function of the Staphylococcus aureus eukaryotic-like serine/threonine protein kinase PknB was investigated by transcriptome analysis using DNA-microarray technology and biochemical assays. The transcriptional profile reveals a strong regulatory impact of PknB on the expression of genes encoding...
ORGANISM(S): Staphylococcus aureus subsp. aureus NCTC 8325 
2010-05-05 | E-GEOD-15346 | biostudies-arrayexpress
MetabolomicsClock regulation of metabolites reveals coupling between transcription and metabolism
The circadian clock is intricately connected with metabolism, however the precise details of these connections are incomplete. Here we used high temporal resolution metabolite profiling to determine circadian regulation of mouse liver and cell autonomous metabolism. In mouse liver, we found ~50% of ...
2017-04-05 | MTBLS292 | MetaboLights
MetabolomicsMTBLS12814: Characterizing Human Oxidative, Anabolic and Glycolytic Metabolism in Athletes with Extreme Physiologies

Background

Regular physical activity is known to benefit health but the long-term effects of specific exercise training on human metabolism remain incompletely described. In this study, we comprehensively characterized the blood metabolomes of male athletes with distinct exercise-adapted me...

2026-03-13 | MTBLS12814 | MetaboLights
MetabolomicsTwo UGT84A Family Glycosyltransferases Regulate Phenol, Flavonoid, and Tannin Metabolism in Juglans regia (English Walnut)
We showed previously that gallic acid is produced in walnut from 3-dehydroshikimate by a shikimate dehydrogenase (JrSkDH). This study focuses on the next step in the hydrolysable tannin pathway, the formation of 1-O-galloyl-β-D-glucose from the phenolic gallic acid and UDP glucose by a glycos...
2022-10-11 | MTBLS2042 | MetaboLights
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