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TranscriptomicsThrombospondin-1 type 1 repeats in a model of inflammatory bowel disease: genetic profile and therapeutic effects
Thrombospondin 1 (TSP-1) is an anti-angiogenic matricellular protein with regulatory functions in inflammation and cancer. The type 1 repeats (TSR) domains of TSP-1 have been shown to interact with a wide range of proteins that result in the anti-angiogenic and anti-tumor properties of TSP-1. To eva...
ORGANISM(S): Mus musculus 
2014-08-26 | E-GEOD-32697 | biostudies-arrayexpress
ProteomicsO-fucosylation of Thrombospondin Type I Repeats on Thrombospondin 1 is dispensable for trafficking to Platelets
Thrombospondin 1 (THBS1) is a secreted extracellular matrix glycoprotein that regulates a variety of cellular and physiological processes. THBS1’s diverse functions are attributed to interactions between the modular domains of THBS1 with an array of proteins found in the extracellular matrix. THBS1’...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-02 | PXD037158 | Pride
Pofut2/o-fucosylation/c-mannosylation/thrombospondin 1/protein trafficking 
TranscriptomicsTranscription profiling of mouse T cell response to ocular pigment epithelial cells - role of thrombospondin 1
Ocular pigment epithelium (PE) cells promote the generation of T regulators (PE-induced Treg cells). Moreover, T cells exposed to PE acquire the capacity to suppress the activation of bystander T cells via TGFbeta. Membrane-bound TGFbeta on iris PE cells interacts with TGFbeta receptors on T cells, ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5134 | biostudies-arrayexpress
GenomicsRegulation of muscle mass by Thrombospondin-1
Regulation of muscle mass by Thrombospondin-1
PRJNA1029530 | ENA
TranscriptomicsProtease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta
During chronic liver disease, tissue remodeling leads to dramatic changes and accumulation of matrix components. Matrix metalloproteases and their inhibitors have been involved in the regulation of matrix degradation. However, the role of other proteases remains incompletely defined. We undertook a ...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-24667 | biostudies-arrayexpress
TranscriptomicsCD47 Inhibits Self-renewal and Reprogramming by Regulating c-Myc and Other Stem Cell Transcription Factors
Signaling through the thrombospondin-1 receptor CD47 broadly limits cell and tissue survival of stress, but the molecular mechanisms are incompletely understood. We now show that loss of CD47 permits sustained proliferation of primary murine endothelial cells and enables these cells to spontaneously...
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-43133 | biostudies-arrayexpress
GenomicsThrombospondin-1 in glioblastoma development
Comparing angiogenic and invasive glioblastoma gene networks. Thrombospondin-1 as the highest connected invasive gene.
PRJEB23786 | ENA
UnknownBiophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2.
Not available
S-EPMC2219889 | biostudies-literature
GenomicsThrombospondin-1 promotes fibro-adipogenic stromal expansion and contractile dysfunction of the diaphragm in obesity
Thrombospondin-1 promotes fibro-adipogenic stromal expansion and contractile dysfunction of the diaphragm in obesity
PRJNA1006029 | ENA
GenomicsThrombospondin-1 promotes fibro-adipogenic stromal expansion and contractile dysfunction of the diaphragm in obesity II
Thrombospondin-1 promotes fibro-adipogenic stromal expansion and contractile dysfunction of the diaphragm in obesity II
PRJNA1006678 | ENA
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