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ProteomicsO-fucosylation of Thrombospondin Type I Repeats on Thrombospondin 1 is dispensable for trafficking to Platelets
Thrombospondin 1 (THBS1) is a secreted extracellular matrix glycoprotein that regulates a variety of cellular and physiological processes. THBS1’s diverse functions are attributed to interactions between the modular domains of THBS1 with an array of proteins found in the extracellular matrix. THBS1’...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-02 | PXD037158 | Pride
Pofut2/o-fucosylation/c-mannosylation/thrombospondin 1/protein trafficking 
UnknownTHBS1 (thrombospondin-1).
Not available
S-EPMC7687907 | biostudies-literature
TranscriptomicsThrombospondin-1 type 1 repeats in a model of inflammatory bowel disease: genetic profile and therapeutic effects
Thrombospondin 1 (TSP-1) is an anti-angiogenic matricellular protein with regulatory functions in inflammation and cancer. The type 1 repeats (TSR) domains of TSP-1 have been shown to interact with a wide range of proteins that result in the anti-angiogenic and anti-tumor properties of TSP-1. To eva...
ORGANISM(S): Mus musculus 
2014-08-26 | E-GEOD-32697 | biostudies-arrayexpress
ProteomicsProteomics reveals the regulation of lentivirus-mediated THBS1 overexpression in ALG1 and its mechanism in meibomian gland carcinoma
Meibomian gland carcinoma (MGC) is an aggressive and poorly prognostic eyelid malignancy. Previous studies have demonstrated that miR-3907 is highly expressed in MGC, accelerating tumor progression by negatively regulating THBS1. This study delves into the downstream regulatory mechanisms of THBS1. ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD059655 | Pride
4d-label-free proteomics meibomian gland carcinoma thrombospondin-1 chitobiosyldiphosphodolichol beta-mannosyltransferase 
TranscriptomicsTranscription profiling of mouse T cell response to ocular pigment epithelial cells - role of thrombospondin 1
Ocular pigment epithelium (PE) cells promote the generation of T regulators (PE-induced Treg cells). Moreover, T cells exposed to PE acquire the capacity to suppress the activation of bystander T cells via TGFbeta. Membrane-bound TGFbeta on iris PE cells interacts with TGFbeta receptors on T cells, ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5134 | biostudies-arrayexpress
ProteomicsmicroRNA-222 Attenuates Mitochondrial Dysfunction Induced by Transmissible Gastroenteritis Virus via Targeting Thrombospondin-1 and Inhibiting Cluster of Differentiation 47
Transmissible gastroenteritis virus (TGEV) is a member of Coronaviridae family. Our previous research showed that TGEV infection could induce mitochondrial dysfunction and up-regulat miR-222 level. Therefore, we presumed that miR-222 might be implicated in regulating mitochondrial dysfunction induce...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2018-12-19 | PXD010927 | Pride
Proteomics Microrna-222 Mitochondrial dysfunction Transmissible gastroenteritis virus Thrombospondin-1 (thbs1) Cluster of differentiation 47 (cd47) 
GenomicsRegulation of muscle mass by Thrombospondin-1
Regulation of muscle mass by Thrombospondin-1
PRJNA1029530 | ENA
GenomicsThrombospondin-1 in glioblastoma development
Comparing angiogenic and invasive glioblastoma gene networks. Thrombospondin-1 as the highest connected invasive gene.
PRJEB23786 | ENA
TranscriptomicsTasquinimod, a Quinoline-3-Carboxamide Anti-Angiogenic Agent, treated Prostate Cancer Cell Line in-vivo and in-vitro
The quinoline-3-carboxamide ABR-215050 (Tasquinimod (INN)), exhibits anti-tumor activity via inhibition of tumor angiogenesis in human and rodent tumors. To further explore the mode of action of ABR-215050, in vivo experiments with gene microarray analysis were performed using samples of LNCaP prost...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-17031 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of the lung in a Thbs1 cell specific knockout model after pseudomonal injury in mice
An early event after lung injury is extracellular matrix (ECM) remodeling and the formation of a provisional matrix. While megakaryocytes (Mgks) and platelets play important roles in hemostasis, their impact on the matrix in lung injury is not fully understood. We utilized quantitative proteomics to...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-20 | PXD071231 | Pride
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