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TranscriptomicsRole of AhR in thymocyte emigration in vivo
Over-activation of the aryl hydrocarbon receptor by TCDD in mice leads among other phenotypes to a severe thymic atrophy accompanied by immunosuppression. TCDD causes a block in thymocyte maturation and a preferential emigration of immature CD4-CD8- DN thymocytes (recent thymic emigrants) into the p...
ORGANISM(S): Mus musculus 
2008-11-25 | E-GEOD-10166 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of thymocyte differentiation in knockout mouse models
Microarray experiment with whole thymi from genetically enginereed mice, with purified thymocyte samples and with cell lines.
ORGANISM(S): Mus musculus 
2004-06-30 | E-MEXP-96 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of seven consecutive stages of mouse thymocyte development
Expression profiles of seven consecutive stages of mouse thymocyte development were generated.
ORGANISM(S): Mus musculus 
2007-12-20 | E-GEOD-272 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse double negative thymocytes
In order to understand the molecular mechanisms of DN thymocyte development, it may be also of use to clarify how these developmental processes are regulated in terms of their entire gene expression, to which cell differentiation is ultimately ascribed. In the current study, we approached this iss...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7784 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of thymocyte subsets
Mouse thymocytes can be classified into four major subsets based on expression of CD4 and CD8 co-receptors. CD4-CD8- (double negative, DN) cells become CD4+CD8+ (double positive, DP) cells following productive T cell receptor (TCR) beta chain rearrangement. A small proportion of DP cells are selecte...
ORGANISM(S): Mus musculus 
2011-08-09 | E-GEOD-31082 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in mature OT-II TCR transgenic CD4 SP thymocytes, either Jmjd3- and Utx-deficient or -sufficient.
The biological functions of histone demethylases Jmjd3 and Utx remain poorly understood. We assessed such functions in developing T cells, using conditional (CD4-Cre-mediated) gene disruption, by inactivating Kdm6a and Kdm6b, respectively encoding Utx and Jmjd3, in immature CD4+CD8+ thymocytes. We c...
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-70363 | biostudies-arrayexpress
TranscriptomicsTissue-specific changes in Tcrb conformation
We report the changes in Tcrb interactome upon transitioning from DN to DP stage of thymocyte development Examination of the interactomes of Eb and Trbv5 viewpoints in RAG-deficient DN and DP thymocytes
ORGANISM(S): Mus musculus 
2015-07-08 | E-GEOD-68955 | biostudies-arrayexpress
GenomicsMevalonate metabolism-dependent protein geranylgeranylation regulates thymocyte egress
Mevalonate metabolism-dependent protein geranylgeranylation regulates thymocyte egress
PRJNA558354 | ENA
TranscriptomicsTranscriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression
The decline in adaptive immunity, naïve T-cell output and a contraction in the peripheral T cell receptor (TCR) repertoire with age are largely attributable to thymic involution and the loss of critical cytokines and hormones within the thymic microenvironment. To assess the molecular changes associ...
ORGANISM(S): Mus musculus 
2009-05-05 | E-GEOD-15945 | biostudies-arrayexpress
GenomicsPre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation
Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation
PRJNA772188 | ENA
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