Thyroid eye disease

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Unknown (271)
Transcriptomics (245)
Genomics (64)
Proteomics (6)
Clinical (2)
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Organisms

Mus musculus (107)
Homo sapiens (49)
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Oncorhynchus mykiss (6)
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Organisms

Homo sapiens (10)
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Repository

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geo (12)
pride (2)
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Tissue

Extracellular space (1)
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Disease

Normal (3)
Oropharynx squamous-cell carcinoma in DiseaseLocation oropharynx has DiseaseStaging lymph node negative (N0) (1)
Rett syndrome (1)
Embryonic lethal at day 8.5 to 9.5 (1)
Cutaneous melanoma (1)
Apparently healthy (1)
Photoreceptor degeneration (1)
Invasive lobular carcinoma (1)
Cancer (1)
Cataract (1)
Carcinoma (1)
Graves ophthalmopathy (1)

Technology Type

Mass Spectrometry (2)
Mass spectrometry (1)
Data-dependent acquisition (1)
Shotgun proteomics (1)

Instrument Platform

Illumina HiSeq 4000 (6)
Illumina NovaSeq 6000 (5)
G2565AA DNA microarray scanner [Agilent] (4)
Illumina HiSeq 2500 (3)
ScanArray Express HT [PerkinElmer] (2)
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Illumina MiSeq (2)
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Axon 4000B (1)
G2565BA DNA microarray scanner [Agilent] (1)
DNBSEQ-T7 (1)
Illumina HiSeq 2000 (1)
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Liquid Chromatography MS - positive - reverse phase (1)

Publication Date

2013 (53)
2015 (38)
2012 (34)
2014 (24)
2010 (18)
2011 (16)
2009 (15)
2008 (15)
2007 (12)
2026 (10)
2016 (10)
2006 (8)
2025 (7)
2017 (7)
2004 (7)
2022 (6)
2021 (4)
2020 (3)
2005 (3)
2024 (2)
2023 (2)
2018 (2)
2019 (1)

Metabolite Name

7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,5-bis({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})-1<U+00CE><U+00BB><U+00E2><U+0081><U+00B4>-chromen-1-ylium (1)
Quercetin 3-(6''-acetylglucoside) (1)
5-hydroxy-2-(4-hydroxyphenyl)-7-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,4-dihydro-2H-1-benzopyran-4-one (1)
Apigenin 7-O-beta-D-glucoside (1)
Quercetin 4',7-diglucoside (1)
(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoic Acid (1)
Demethylnobiletin (1)
4-Methoxybenzoate (1)
2,5-Dihydroxybenzoate (1)
Pteroyl-D-glutamic acid (1)
(-)-Epicatechin 3-O-gallate (1)
(3'alpha,5'alpha,9'xi,10'beta)-O-(3-Hydroxy-7-drimen-11-yl)umbelliferone (1)
BICINE (1)
Desmethylxanthohumol (1)
Cyanidin 3-sambubioside 5-glucoside (1)
Gibberellin A54 (1)
Melanin (1)
Fenitrothion (1)
Glechomafuran (1)
Gibberellin A124 (1)
Macelignan (1)
M-toluic Acid (1)
11,12-Dimethoxydihydrokawain (1)
2-Methoxyestradiol (1)
Bosentan (1)
Liriodendrin (1)
2-(N-Methyl-perfluorooctane sulfanamido) acetic acid (1)
7alpha,8alpha-Dihydroxycalonectrin (1)
Austalide D (1)
Atazanavir (1)

First Public Date

2026 (11)
2025 (2)
2023 (2)
2015 (2)
2014 (2)
2024 (1)
2022 (1)
2017 (1)

Study status

Recruiting (1)
Completed (1)

Study type

Transcription profiling by array (173)
ChIP-seq (36)
RNA-seq of coding RNA (31)
RNA-seq of non coding RNA (8)
RNA-seq of coding RNA from single cells (4)
ChIP-chip by array (3)
Comparative genomic hybridization by array (3)
Other (3)
Methylation profiling by high throughput sequencing (3)
ChIP-chip by tiling array (2)
Animal - High-throughput sequencing (2)
Methylation profiling by array (2)
Proteomic profiling by array (2)
Unknown experiment type (1)
Cell line - One-color microarray (1)
Transcription profiling by tiling array (1)
Transcription profiling by RT-PCR (1)
DNA-seq (1)
Observational patient registry (1)
Observational (1)

Release Date

2013 (54)
2025 (53)
2022 (47)
2015 (46)
2023 (41)
2024 (39)
2012 (36)
2021 (33)
2014 (26)
2016 (19)
2010 (18)
2011 (17)
2020 (16)
2009 (15)
2008 (15)
2019 (13)
2018 (13)
2017 (11)
2007 (11)
2026 (9)
2006 (8)
2004 (8)
2005 (3)

Lab affiliation

Byers Eye Institute, Stanford University (1)
OPTICS group, Departement de Science des Protéines Humaines, Rue Michel Servet-1, 1206 Geneva, Switzerland (1)

Location

United States (2)
Australia (1)

Keyword

Neglected Diseases (1)
Orphan Diseases (1)
Rare Disease Research (1)
Registries (1)
Batten Disease (1)
Mucolipidosis IV (1)
Undiagnosed (1)
Uncommon Disease (1)
Hypersomnia (1)
Marinesco-Sjogren Syndrome (1)
4p-/Wolf-Hirschhorn Syndrome (1)
Wiedermann-Steiner Syndrome (1)
Hemophagocytic Lymphohistiocytosis (HLH) (1)
Behcet’s Disease (1)
Jansen metaphyseal chondrodysplasia (1)
Chronic recurrent multifocal osteomyelitis (CRMO) (1)
Hereditary Sensory and Autonomic Neuropathy (1)
Nephropathic infantile cystinosis (1)
Ocular cystinosis (1)
Spinal Bulbar Muscular Atrophy (SBMA) (1)
Mucolipidosis (1)
Mitochondrial aminoacyl-tRNA synthetases (Mt-aaRS Disorders) (1)
Shine Syndrome (1)
Intestinal Bromhidrosis Syndrome (1)
Autosomal recessive extra oral halitosis (1)
CACNA1H mutation (1)
Dimethylglycine dehydrogenase deficiency (1)

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Transcription profiling of rat eye eQTL experiment

We used expression quantitative trait locus mapping in the laboratory rat (Rattus norvegicus) to gain a broad perspective of gene regulation in the mammalian eye and to identify genetic variation relevant to human eye disease. Of >31,000 gene probes represented on an Affymetrix expression microarray...

ORGANISM(S): Rattus norvegicus

2008-06-14 | E-GEOD-5680 | biostudies-arrayexpress

scRNAseq of cell from orbital fat in thyroid eye disease

scRNAseq of thyroid eye disease orbital fat demonstrates fibroblast thyroid hormone signaling and SPARC production Orbital fat from four people undergoing decompression surgery for TED was digested to single cells and sequenced. Two donors' cells were hashed and combined into each sample. (i.e. fou...

ORGANISM(S): Homo sapiens

2026-06-26 | E-MTAB-16698 | biostudies-arrayexpress

Proteomic analysis of the thryoid eye disease tear film

Thyroid eye disease (TED) is a complex autoimmune disease that is often disfiguring and sight threatening. Recent advances have shifted the treatment paradigm from traditional immunosuppressive therapies such as corticosteroids to targeted biologic agents, such as teprotumumab (TMB; anti-IGF-1R) whi...

ORGANISM(S): Homo sapiens (Human)

2026-06-08 | PXD066511 | Pride

scRNAseq of cell from orbital fat in thyroid eye disease

PRJEB108944 | ENA

The cardiac calsequestrin gene (CASQ2) is up-regulated in the thyroid in patients with Graves’ ophthalmopathy

Thyroid-associated ophthalmopathy (TAO) is a complex eye and orbital disorder that is uniquely linked to Graves’ hyperthyroidism (GH). A popular explanation for the development of orbital inflammation in these patients is autoimmunity against the TSH-receptor expressed in orbital preadipocytes. How...

ORGANISM(S): Homo sapiens

2007-10-16 | E-GEOD-9340 | biostudies-arrayexpress

A Transcriptome-based Molecular Classification Scheme for Thyroid Eye Disease

PRJNA1201766 | ENA

microRNA-seq data of orbital connective tissues from thyroid eye disease patients

PRJNA1174108 | ENA

Establishment of biomarkers to predict response to glucocorticoids for thyroid eye disease by DIA proteome analysis.

The standard treatment for thyroid eye disease is glucocorticoid administration, however its response varies from case to case. In recent years, treatment of thyroid eye disease has evolved dramatically, and the efficacy of several agents is being demonstrated. If steroid resistance is identified pr...

ORGANISM(S): Homo Sapiens (human)

2026-03-12 | PXD061741 | JPOST Repository

Future Projections in Thyroid Eye Disease.

Not available

S-EPMC9359449 | biostudies-literature

Clinical pathophysiology of thyroid eye disease: The Cone Model.

Not available

S-EPMC6367424 | biostudies-literature

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