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MetabolomicsExploring Lipidomic Profiles and Their Correlation with Hormone Receptor and HER2 Status in Breast Cancer
Dysregulated lipid metabolism promotes the progression of various cancers, including breast cancer. This study aimed to explore the lipidomic profiles of breast cancer patients, providing insights into the correlation between lipid compositions and tumor subtypes characterized by hormone receptor (H...
2024-08-16 | MTBLS10858 | MetaboLights
MetabolomicsSerum metabolomic profiles associated with postmenopausal hormone use

INTRODUCTION: Postmenopausal hormone use is linked to several health outcomes and the risk associated with some may differ depending on whether estrogen is used alone or in combination with progestin.

OBJECTIVE: Metabolomic analyses of postmenopausal hormon...

2019-06-02 | MTBLS136 | MetaboLights
MetabolomicsAlterations in the amino acid profile in patients with papillary thyroid carcinoma with and without Hashimoto’s thyroiditis

PURPOSE: Amino acids (AAs) play important physiological roles in living cells. Some amino acid changes in blood are specific for autoimmune disorders, and some are specific for thyroid cancer. The aims of this study were to profile AA metabolites in the serum of patients with pap...

2023-08-09 | MTBLS8012 | MetaboLights
TranscriptomicsCharacterization of Directly Regulated Thyroid Hormone Mediated Gene Expression Following Short-Term Perturbations in Thyroid Hormone Levels in Juvenile Mice
We investigated the effects of thyroid hormone disruptions on gene expression in juvenile mice liver to develop a stronger understanding of the mechanisms by which thyroid disrupting chemicals impair development. Gene expression was examined by hybridization of hepatic RNA to Agilent mouse microarr...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-21307 | biostudies-arrayexpress
ProteomicsSex Impacts Cardiac Function and the Proteome Response to Thyroid Hormone in Aged Mice
Background: Sex and age have substantial influence on thyroid function. Sex influences the risk and clinical expression of thyroid disorders (TDs), with age a proposed trigger for the development of TDs. Cardiac function is affected by thyroid hormone levels with gender differences. Accordingly, we...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-23 | PXD022557 | Pride
Heart Aged Thyroid hormone Lc-ms/ms 
ProteomicsThyroid Hormone Dependent Transcriptional Programming by TRb Requires SWI/SNF Chromatin Remodelers
Transcriptional regulation in response to thyroid hormone (3,5,3´-triiodo-L-thyronine, T3) is a dynamic and cell-type specific process that maintains cellular homeostasis and identity in all tissues. However, our understanding of the mechanisms of thyroid hormone receptor (TR) actions at the molecul...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030403 | Pride
Transcription Coregulators Thyroid hormone receptor Nuclear receptor 
TranscriptomicsGene Expression Profile in thyroid of Transgenic Mice over-expressing the Adenosine Receptor 2a
Mutations of the thyrotropin receptor leading to constitutive activation of the cAMP cascade are responsible for the development of hot nodules, if arising in a somatic cell, and non-auto-immune hyperthyroidism, when occurring in a germinal cell. An animal model of constitutive activation of the thy...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-780 | biostudies-arrayexpress
TranscriptomicsIsoform-specific transcriptional activity of overlapping targets that respond to thyroid hormone receptors a1 and b1
Thyroid hormone receptors (TRs) are hormone-regulated transcription factors that control multiple aspects of physiology and development. TRs are expressed in vertebrates as a series of distinct isoforms that exert distinct biological roles. We wished to determine if the two most widely expressed i...
ORGANISM(S): Homo sapiens 
2009-08-08 | E-GEOD-17561 | biostudies-arrayexpress
TranscriptomicsIn Vivo Regulation of Human Skeletal Muscle Gene Expression by Thyroid Hormone
This SuperSeries is composed of the following subset Series: GSE3461: Gene expression in miscellaneous human tissues and cell lines GSE3462: Triiodothyronine Treatment: Effects on vastus lateralis skeletal muscle Abstract: Thyroid hormones are key regulators of metabolism that modulate transcriptio...
ORGANISM(S): Homo sapiens 
2006-03-06 | E-GEOD-4345 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hearts from wild type and thyroid hormone receptor beta-mutant mice (d337T TRb) treated with or without PPARalpha activator to study the molecular effect of thyroid hormone receptor on PPARalpha activation.
In this study we used the d337T TRb transgenic mouse that has been created to reproduce the human genetic disease known as resistance to thyroid hormone (RTH) as a model to determine if the d337T TRb mutation would have an effect on PPARa activation. A single amino acid deletion (d337T) abrogates ...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-3067 | biostudies-arrayexpress
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