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ProteomicsSex Impacts Cardiac Function and the Proteome Response to Thyroid Hormone in Aged Mice
Background: Sex and age have substantial influence on thyroid function. Sex influences the risk and clinical expression of thyroid disorders (TDs), with age a proposed trigger for the development of TDs. Cardiac function is affected by thyroid hormone levels with gender differences. Accordingly, we...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-23 | PXD022557 | Pride
Heart Aged Thyroid hormone Lc-ms/ms 
TranscriptomicsCharacterization of Directly Regulated Thyroid Hormone Mediated Gene Expression Following Short-Term Perturbations in Thyroid Hormone Levels in Juvenile Mice
We investigated the effects of thyroid hormone disruptions on gene expression in juvenile mice liver to develop a stronger understanding of the mechanisms by which thyroid disrupting chemicals impair development. Gene expression was examined by hybridization of hepatic RNA to Agilent mouse microarr...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-21307 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression analysis of iodide treated rat thyroid follicular cell line PCCl3
The inhibitory effect of supra physiological iodide concentrations on thyroid hormone synthesis (Wolff-Chaikoff effect) and thyrocyte proliferation is largely know as iodine autoregulation. However, the molecular mechanisms by which iodide excess modulate thyroid functions remains unclear. In this w...
ORGANISM(S): Rattus norvegicus 
2007-11-01 | E-GEOD-7174 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression in thyrocytes between wildtype and thyroid-specific IFNg transgenic mice
Hürthle cells are found in thyroid tumors and autoimmunity, and have a unique appearance characterized by swollen eosinophilic cytoplasm filled with mitochondria and hyperchromatic nucleus. The pathogenesis of Hürthle cells remains unknown. We have generated transgenic mice expressing IFNg specifica...
ORGANISM(S): Mus musculus 
2009-07-01 | E-GEOD-15114 | biostudies-arrayexpress
TranscriptomicsExposure to Propylthiouracil in Pregnant Mice Potentiates the Transcriptional Response to Thyroid Hormone in the Fetal Cerebral Cortex
Although the effects of thyroid hormones (TH) on the brain development have been extensively studied perinatally, effects of TH of maternal origin on the fetal brain development have been largely unexplored. We applied a high throughput study on the mouse models with aberrant TH levels on gestation ...
ORGANISM(S): Mus musculus 
2014-02-04 | E-GEOD-43927 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in NCoR deficient mouse livers
The thyroid hormone receptor (TR) has been proposed to regulate target genes in the absence of triiodothyronine (T3), through the recruitment of the corepressors, NCoR and SMRT. NCoR and SMRT may thus play a key role in both hypothyroidism and resistance to thyroid hormone, though this has never bee...
ORGANISM(S): Mus musculus 
2008-12-03 | E-GEOD-10001 | biostudies-arrayexpress
TranscriptomicsIsoform-specific transcriptional activity of overlapping targets that respond to thyroid hormone receptors a1 and b1
Thyroid hormone receptors (TRs) are hormone-regulated transcription factors that control multiple aspects of physiology and development. TRs are expressed in vertebrates as a series of distinct isoforms that exert distinct biological roles. We wished to determine if the two most widely expressed i...
ORGANISM(S): Homo sapiens 
2009-08-08 | E-GEOD-17561 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human thyroid gland cells to find molecular signatures of thyroid follicular neoplasia
Sixty-nine (69) tumor samples were collected from patients who underwent thyroidectomy.

The tumors included 22 benign follicular adenomas, 18 follicular carcinomas, 12 samples of microfollicular adenomas, 4 anaplastic carcinomas, 2 papillary carcinomas, and 9 nodular goiters. 23 samples were ...
ORGANISM(S): Homo sapiens 
2010-08-05 | E-MEXP-2442 | biostudies-arrayexpress
TranscriptomicsInterferon-alpha mediates the development of autoimmunity by direct tissue toxicity and through immune-cell recruitment mechanisms
Interferon-alpha is a major therapeutic agent for many diverse diseases. However, the interferon-alpha mechanism of therapeutic action and associated side effects are not well understood. In particular, thyroiditis is a common unexplained complication. We hypothesized that direct thyroid-toxic act...
ORGANISM(S): Mus musculus 
2011-11-03 | E-GEOD-25115 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brains, hindlimbs and tails of Xenopus laevis tadpoles after treatment with thyroid hormone
Premetamorphic Xenopus laevis tadpole tail respond to thyroid hormone by resorption. The goal of this experiment is to identify the genes involved in the TH-induced resorption tadpole tail and compare it to TH-induced proliferation and differentiation program in tadpole limb and brain. Xenopus tadpo...
ORGANISM(S): Xenopus laevis 
2006-11-08 | E-MNIA-94 | biostudies-arrayexpress
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